AmiGO 2: Term Details for "thyroxine 5'-deiodinase activity" (GO:0004800)

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Term Information

Accession: GO:0004800
Name: thyroxine 5'-deiodinase activity
Ontology: molecular_function
Synonyms: outer ring-deiodinating pathway, thyroxine 5' deiodinase activity, L-thyroxine iodohydrolase (reducing) activity, acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating), diiodothyronine 5'-deiodinase activity, iodothyronine 5'-deiodinase activity, iodothyronine outer ring monodeiodinase activity, type I iodothyronine deiodinase activity, type II iodothyronine deiodinase activity, thyroxine deiodinase activity
Alternate IDs: None
Definition: Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2. Source: EC:1.21.99.4
Comment: None
History: See term history for GO:0004800 at QuickGO
Chem. react.: has participant hydrogen donor; has participant hydrogen acceptor; has participant 3,3',5-triiodo-L-thyronine zwitterion; has participant iodide; has participant hydron; has participant L-thyroxine zwitterion
Subset: None
Related: Link to all genes and gene products annotated to thyroxine 5'-deiodinase activity (excluding "regulates").; Link to all direct and indirect annotations to thyroxine 5'-deiodinase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for thyroxine 5'-deiodinase activity (excluding "regulates").

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Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0004800 thyroxine 5'-deiodinase activity

Parents of thyroxine 5'-deiodinase activity (GO:0004800)

subject	relation	object
thyroxine 5'-deiodinase activity	RO:0000057	hydrogen donor (CHEBI:17499)
thyroxine 5'-deiodinase activity	RO:0000057	hydrogen acceptor (CHEBI:13193)
thyroxine 5'-deiodinase activity	RO:0000057	3,3',5-triiodo-L-thyronine zwitterion (CHEBI:533015)
thyroxine 5'-deiodinase activity	RO:0000057	iodide (CHEBI:16382)
thyroxine 5'-deiodinase activity	RO:0000057	hydron (CHEBI:15378)
thyroxine 5'-deiodinase activity	RO:0000057	L-thyroxine zwitterion (CHEBI:58448)
thyroxine 5'-deiodinase activity	is_a	oxidoreductase activity (GO:0016491)

This term has no children.

EC: 1.21.99.4
MetaCyc: THYROXINE-DEIODINASE-RXN
Reactome: R-HSA-209772; R-HSA-350869
RHEA: 19745