Term Information

Accession

GO:0031499

Ontology

cellular component

Synonyms

narrow: TRAMP4 complex

narrow: TRAMP5 complex

narrow: Trf4 complex

narrow: Trf4 poly(A) polymerase complex

narrow: Trf4p-Air2p-Mtr4p polyadenylation complex

Definition

A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control. [source: PMID:15173578, PMID:15828860, PMID:15935758, PMID:15935759, PMID:16373491, PMID:16374505, PMID:16431988, PMID:16973437, PMID:17410208, PMID:17652137]

Comment

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Subset

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External References

Wikipedia (1)

• TRAMP_complex

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