Term Information

Accession

GO:0017101

Ontology

cellular component

Synonyms

exact: aminoacyl-tRNA synthetase complex

exact: multisynthetase complex

Definition

A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates. [source: GOC:jl, PMID:16169847]

Comment

None

Subset

None

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Term Lineage

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External References

JCVI_TIGRFAMS (1)

• TIGR00467

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