cholesterol 7-alpha-monooxygenase activity

Term information
Term lineage
External references
5 gene product associations

Term Information

Accession: GO:0008123
Ontology: molecular function
Synonyms: narrow: cytochrome P450 CYP7A1; exact: cholesterol 7-alpha-hydroxylase activity; exact: cholesterol 7alpha-hydroxylase activity; exact: cholesterol 7alpha-monooxygenase activity; exact: cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
Definition: Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. [source: EC:1.14.13.17]
Comment: None
Subset: None
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all : all [269974 gene products]
- GO:0003674 : molecular_function [183428 gene products]
- - GO:0003824 : catalytic activity [57076 gene products]
  - - GO:0016491 : oxidoreductase activity [9206 gene products]
    - - GO:0004497 : monooxygenase activity [1295 gene products]
      - GO:0016709 : oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [222 gene products]
        
        GO:0008123 : cholesterol 7-alpha-monooxygenase activity [5 gene products]
        
        GO:0008395 : steroid hydroxylase activity [40 gene products]
        
        GO:0008123 : cholesterol 7-alpha-monooxygenase activity [5 gene products]
      - GO:0016705 : oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [973 gene products]
      - GO:0016709 : oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [222 gene products]
        
        GO:0008123 : cholesterol 7-alpha-monooxygenase activity [5 gene products]

External References

EC (1)

1.14.13.17

MetaCyc (1)

CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN

Reactome (1)

22932