I-kappaB kinase/NF-kappaB cascade

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Term lineage
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159 gene product associations

Term Information

Accession: GO:0007249
Ontology: biological process
Synonyms: related: activation of the inhibitor of kappa kinase; exact: NIK-I-kappaB/NF-kappaB cascade
Definition: A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase. [source: GOC:jl, PMID:12773372]
Comment: None
Subset: None
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all : all [18608 gene products]
- GO:0008150 : biological_process [15006 gene products]
- - GO:0065007 : biological regulation [7836 gene products]
  - - GO:0050789 : regulation of biological process [7430 gene products]
    - - GO:0050794 : regulation of cellular process [7174 gene products]
      - GO:0007165 : signal transduction [3740 gene products]
        
        GO:0007242 : intracellular signaling cascade [1535 gene products]
        
        GO:0007243 : protein kinase cascade [543 gene products]
        
        GO:0007249 : I-kappaB kinase/NF-kappaB cascade [159 gene products]
  - GO:0009987 : cellular process [12538 gene products]
  - - GO:0007154 : cell communication [4149 gene products]
    - - GO:0007165 : signal transduction [3740 gene products]
      - GO:0007242 : intracellular signaling cascade [1535 gene products]
        
        GO:0007243 : protein kinase cascade [543 gene products]
        
        GO:0007249 : I-kappaB kinase/NF-kappaB cascade [159 gene products]
    - GO:0050794 : regulation of cellular process [7174 gene products]
    - - GO:0007165 : signal transduction [3740 gene products]
      - GO:0007242 : intracellular signaling cascade [1535 gene products]
        
        GO:0007243 : protein kinase cascade [543 gene products]
        
        GO:0007249 : I-kappaB kinase/NF-kappaB cascade [159 gene products]
  - GO:0050789 : regulation of biological process [7430 gene products]
  - - GO:0050794 : regulation of cellular process [7174 gene products]
    - - GO:0007165 : signal transduction [3740 gene products]
      - GO:0007242 : intracellular signaling cascade [1535 gene products]
        
        GO:0007243 : protein kinase cascade [543 gene products]
        
        GO:0007249 : I-kappaB kinase/NF-kappaB cascade [159 gene products]

External References

MIPS_funcat (1)

30.01.05.01.04

Reactome (5)