complement activation, classical pathway

Term information
Term lineage
External references
29 gene product associations

Term Information

Accession: GO:0006958
Ontology: biological process
Synonyms: None
Definition: Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes. [source: GOC:add, ISBN:0781735149]
Comment: None
Subset: None
Community: There have been 0 comments for this term. If you would like to view or participate in the community annotation, please continue to the GONUTS page.

Term Lineage

Switch to viewing term parents, siblings and children

Current filters: Species:

Filter tree view: Filter Gene Product Counts
Data source
Species

View Options
Tree view Full Compact

Actions...
Last action: Reset the tree
Graphical View
View in tree browser
Download...
OBO
RDF-XML
GraphViz dot

all : all [18608 gene products]
- GO:0008150 : biological_process [15006 gene products]
- - GO:0065007 : biological regulation [7836 gene products]
  - - GO:0050789 : regulation of biological process [7430 gene products]
    - - GO:0048518 : positive regulation of biological process [1993 gene products]
      - GO:0002684 : positive regulation of immune system process [239 gene products]
        
        GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
        
        GO:0048584 : positive regulation of response to stimulus [239 gene products]
        
        GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0002682 : regulation of immune system process [379 gene products]
      - GO:0002684 : positive regulation of immune system process [239 gene products]
        
        GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
        
        GO:0050776 : regulation of immune response [226 gene products]
        
        GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0048583 : regulation of response to stimulus [465 gene products]
      - GO:0048584 : positive regulation of response to stimulus [239 gene products]
        
        GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
        
        GO:0050776 : regulation of immune response [226 gene products]
        
        GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
  - GO:0002376 : immune system process [1296 gene products]
  - - GO:0002253 : activation of immune response [103 gene products]
    - - GO:0006956 : complement activation [42 gene products]
      - GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0002252 : immune effector process [206 gene products]
    - - GO:0006956 : complement activation [42 gene products]
      - GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0002443 : leukocyte mediated immunity [129 gene products]
      - GO:0002449 : lymphocyte mediated immunity [107 gene products]
        
        GO:0019724 : B cell mediated immunity [70 gene products]
        
        GO:0016064 : immunoglobulin mediated immune response [69 gene products]
        
        GO:0002455 : humoral immune response mediated by circulating immunoglobulin [37 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0006955 : immune response [959 gene products]
    - - GO:0002250 : adaptive immune response [111 gene products]
      - GO:0002460 : adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [110 gene products]
        
        GO:0019724 : B cell mediated immunity [70 gene products]
        
        GO:0016064 : immunoglobulin mediated immune response [69 gene products]
        
        GO:0002455 : humoral immune response mediated by circulating immunoglobulin [37 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0006959 : humoral immune response [86 gene products]
      - GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
        
        GO:0002455 : humoral immune response mediated by circulating immunoglobulin [37 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0002252 : immune effector process [206 gene products]
      - GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
        
        GO:0002443 : leukocyte mediated immunity [129 gene products]
        
        GO:0002449 : lymphocyte mediated immunity [107 gene products]
        
        GO:0019724 : B cell mediated immunity [70 gene products]
        
        GO:0016064 : immunoglobulin mediated immune response [69 gene products]
        
        GO:0002455 : humoral immune response mediated by circulating immunoglobulin [37 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
      - GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0050776 : regulation of immune response [226 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0002684 : positive regulation of immune system process [239 gene products]
    - - GO:0050778 : positive regulation of immune response [145 gene products]
      - GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0002682 : regulation of immune system process [379 gene products]
    - - GO:0002684 : positive regulation of immune system process [239 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0050776 : regulation of immune response [226 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
  - GO:0008152 : metabolic process [8526 gene products]
  - - GO:0043170 : macromolecule metabolic process [6298 gene products]
    - - GO:0010467 : gene expression [3796 gene products]
      - GO:0051604 : protein maturation [118 gene products]
        
        GO:0016485 : protein processing [108 gene products]
        
        GO:0051605 : protein processing by peptide bond cleavage [87 gene products]
        
        GO:0002541 : activation of plasma proteins involved in acute inflammatory response [45 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0019538 : protein metabolic process [3080 gene products]
      - GO:0051604 : protein maturation [118 gene products]
        
        GO:0016485 : protein processing [108 gene products]
        
        GO:0051605 : protein processing by peptide bond cleavage [87 gene products]
        
        GO:0002541 : activation of plasma proteins involved in acute inflammatory response [45 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
        
        GO:0006508 : proteolysis [1124 gene products]
        
        GO:0051605 : protein processing by peptide bond cleavage [87 gene products]
        
        GO:0002541 : activation of plasma proteins involved in acute inflammatory response [45 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0044238 : primary metabolic process [7721 gene products]
    - - GO:0019538 : protein metabolic process [3080 gene products]
      - GO:0051604 : protein maturation [118 gene products]
        
        GO:0016485 : protein processing [108 gene products]
        
        GO:0051605 : protein processing by peptide bond cleavage [87 gene products]
        
        GO:0002541 : activation of plasma proteins involved in acute inflammatory response [45 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
        
        GO:0006508 : proteolysis [1124 gene products]
        
        GO:0051605 : protein processing by peptide bond cleavage [87 gene products]
        
        GO:0002541 : activation of plasma proteins involved in acute inflammatory response [45 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
  - GO:0048518 : positive regulation of biological process [1993 gene products]
  - - GO:0002684 : positive regulation of immune system process [239 gene products]
    - - GO:0050778 : positive regulation of immune response [145 gene products]
      - GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0048584 : positive regulation of response to stimulus [239 gene products]
    - - GO:0050778 : positive regulation of immune response [145 gene products]
      - GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
  - GO:0050789 : regulation of biological process [7430 gene products]
  - - GO:0048518 : positive regulation of biological process [1993 gene products]
    - - GO:0002684 : positive regulation of immune system process [239 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0048584 : positive regulation of response to stimulus [239 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0002682 : regulation of immune system process [379 gene products]
    - - GO:0002684 : positive regulation of immune system process [239 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0050776 : regulation of immune response [226 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0048583 : regulation of response to stimulus [465 gene products]
    - - GO:0048584 : positive regulation of response to stimulus [239 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0050776 : regulation of immune response [226 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
  - GO:0050896 : response to stimulus [3793 gene products]
  - - GO:0006955 : immune response [959 gene products]
    - - GO:0002250 : adaptive immune response [111 gene products]
      - GO:0002460 : adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [110 gene products]
        
        GO:0019724 : B cell mediated immunity [70 gene products]
        
        GO:0016064 : immunoglobulin mediated immune response [69 gene products]
        
        GO:0002455 : humoral immune response mediated by circulating immunoglobulin [37 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0006959 : humoral immune response [86 gene products]
      - GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
        
        GO:0002455 : humoral immune response mediated by circulating immunoglobulin [37 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0002252 : immune effector process [206 gene products]
      - GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
        
        GO:0002443 : leukocyte mediated immunity [129 gene products]
        
        GO:0002449 : lymphocyte mediated immunity [107 gene products]
        
        GO:0019724 : B cell mediated immunity [70 gene products]
        
        GO:0016064 : immunoglobulin mediated immune response [69 gene products]
        
        GO:0002455 : humoral immune response mediated by circulating immunoglobulin [37 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
      - GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0050776 : regulation of immune response [226 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0048584 : positive regulation of response to stimulus [239 gene products]
    - - GO:0050778 : positive regulation of immune response [145 gene products]
      - GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0048583 : regulation of response to stimulus [465 gene products]
    - - GO:0048584 : positive regulation of response to stimulus [239 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0050776 : regulation of immune response [226 gene products]
      - GO:0050778 : positive regulation of immune response [145 gene products]
        
        GO:0002253 : activation of immune response [103 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0009605 : response to external stimulus [936 gene products]
    - - GO:0009611 : response to wounding [579 gene products]
      - GO:0006954 : inflammatory response [361 gene products]
        
        GO:0002526 : acute inflammatory response [102 gene products]
        
        GO:0002541 : activation of plasma proteins involved in acute inflammatory response [45 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
    - GO:0006950 : response to stress [1781 gene products]
    - - GO:0006952 : defense response [675 gene products]
      - GO:0006954 : inflammatory response [361 gene products]
        
        GO:0002526 : acute inflammatory response [102 gene products]
        
        GO:0002541 : activation of plasma proteins involved in acute inflammatory response [45 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]
      - GO:0009611 : response to wounding [579 gene products]
      - GO:0006954 : inflammatory response [361 gene products]
        
        GO:0002526 : acute inflammatory response [102 gene products]
        
        GO:0002541 : activation of plasma proteins involved in acute inflammatory response [45 gene products]
        
        GO:0006956 : complement activation [42 gene products]
        
        GO:0006958 : complement activation, classical pathway [29 gene products]

External References

Reactome (1)

173623

SP_KW (1)

KW-0180