apoptosis
Term Information
- Accession
- GO:0006915
- Ontology
- biological process
- Synonyms
- related: signaling (initiator) caspase activity
- narrow: apoptotic program
- narrow: type I programmed cell death
- alt_id: GO:0008632
- exact: apoptotic cell death
- exact: apoptotic programmed cell death
- exact: programmed cell death by apoptosis
- Definition
- A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. [source:
GOC:go_curators, ISBN:0198506732, PMID:18846107]
- Comment
- None
- Subset
- None
- Community
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