GPI anchor biosynthetic process

Term information
Term lineage
External references
363 gene product associations

Term Information

Accession

GO:0006506

Ontology

biological process

Synonyms

alt_id: GO:0015998

exact: glycosylphosphatidylinositol biosynthesis

exact: glycosylphosphatidylinositol biosynthetic process

exact: GPI anchor anabolism

exact: GPI anchor biosynthesis

exact: GPI anchor formation

exact: GPI anchor synthesis

broad: GPI/GSI anchor biosynthesis

broad: GPI/GSI anchor biosynthetic process

Definition

The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. [source: GOC:go_curators, ISBN:0198547684]

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all : all [447992 gene products]
- GO:0008150 : biological_process [343845 gene products]
- - GO:0009987 : cellular process [189377 gene products]
  - - GO:0044237 : cellular metabolic process [140471 gene products]
    - - GO:0044249 : cellular biosynthetic process [79764 gene products]
      - GO:0034645 : cellular macromolecule biosynthetic process [55045 gene products]
        
        GO:0042158 : lipoprotein biosynthetic process [588 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0045017 : glycerolipid biosynthetic process [749 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0008654 : phospholipid biosynthetic process [1500 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
      - GO:0044255 : cellular lipid metabolic process [9161 gene products]
      - GO:0046486 : glycerolipid metabolic process [1411 gene products]
        
        GO:0045017 : glycerolipid biosynthetic process [749 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0006650 : glycerophospholipid metabolic process [1117 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0030384 : phosphoinositide metabolic process [801 gene products]
        
        GO:0006505 : GPI anchor metabolic process [394 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0006644 : phospholipid metabolic process [2779 gene products]
        
        GO:0006650 : glycerophospholipid metabolic process [1117 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0030384 : phosphoinositide metabolic process [801 gene products]
        
        GO:0006505 : GPI anchor metabolic process [394 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0008654 : phospholipid biosynthetic process [1500 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
      - GO:0044260 : cellular macromolecule metabolic process [90126 gene products]
      - GO:0034645 : cellular macromolecule biosynthetic process [55045 gene products]
        
        GO:0042158 : lipoprotein biosynthetic process [588 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0044267 : cellular protein metabolic process [43179 gene products]
        
        GO:0006464 : protein modification process [18655 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0042157 : lipoprotein metabolic process [716 gene products]
        
        GO:0042158 : lipoprotein biosynthetic process [588 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
  - GO:0008152 : metabolic process [179341 gene products]
  - - GO:0009058 : biosynthetic process [82384 gene products]
    - - GO:0044249 : cellular biosynthetic process [79764 gene products]
      - GO:0034645 : cellular macromolecule biosynthetic process [55045 gene products]
        
        GO:0042158 : lipoprotein biosynthetic process [588 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0045017 : glycerolipid biosynthetic process [749 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0008654 : phospholipid biosynthetic process [1500 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
      - GO:0008610 : lipid biosynthetic process [6688 gene products]
      - GO:0045017 : glycerolipid biosynthetic process [749 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0008654 : phospholipid biosynthetic process [1500 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
      - GO:0009059 : macromolecule biosynthetic process [55833 gene products]
      - GO:0034645 : cellular macromolecule biosynthetic process [55045 gene products]
        
        GO:0042158 : lipoprotein biosynthetic process [588 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
    - GO:0044237 : cellular metabolic process [140471 gene products]
    - - GO:0044249 : cellular biosynthetic process [79764 gene products]
      - GO:0034645 : cellular macromolecule biosynthetic process [55045 gene products]
        
        GO:0042158 : lipoprotein biosynthetic process [588 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0045017 : glycerolipid biosynthetic process [749 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0008654 : phospholipid biosynthetic process [1500 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
      - GO:0044255 : cellular lipid metabolic process [9161 gene products]
      - GO:0046486 : glycerolipid metabolic process [1411 gene products]
        
        GO:0045017 : glycerolipid biosynthetic process [749 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0006650 : glycerophospholipid metabolic process [1117 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0030384 : phosphoinositide metabolic process [801 gene products]
        
        GO:0006505 : GPI anchor metabolic process [394 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0006644 : phospholipid metabolic process [2779 gene products]
        
        GO:0006650 : glycerophospholipid metabolic process [1117 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0030384 : phosphoinositide metabolic process [801 gene products]
        
        GO:0006505 : GPI anchor metabolic process [394 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0008654 : phospholipid biosynthetic process [1500 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
      - GO:0044260 : cellular macromolecule metabolic process [90126 gene products]
      - GO:0034645 : cellular macromolecule biosynthetic process [55045 gene products]
        
        GO:0042158 : lipoprotein biosynthetic process [588 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0044267 : cellular protein metabolic process [43179 gene products]
        
        GO:0006464 : protein modification process [18655 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0042157 : lipoprotein metabolic process [716 gene products]
        
        GO:0042158 : lipoprotein biosynthetic process [588 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
    - GO:0043170 : macromolecule metabolic process [103729 gene products]
    - - GO:0044260 : cellular macromolecule metabolic process [90126 gene products]
      - GO:0034645 : cellular macromolecule biosynthetic process [55045 gene products]
        
        GO:0042158 : lipoprotein biosynthetic process [588 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0044267 : cellular protein metabolic process [43179 gene products]
        
        GO:0006464 : protein modification process [18655 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0042157 : lipoprotein metabolic process [716 gene products]
        
        GO:0042158 : lipoprotein biosynthetic process [588 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
      - GO:0009059 : macromolecule biosynthetic process [55833 gene products]
      - GO:0034645 : cellular macromolecule biosynthetic process [55045 gene products]
        
        GO:0042158 : lipoprotein biosynthetic process [588 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
      - GO:0043412 : macromolecule modification [21115 gene products]
      - GO:0006464 : protein modification process [18655 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
      - GO:0019538 : protein metabolic process [53200 gene products]
      - GO:0044267 : cellular protein metabolic process [43179 gene products]
        
        GO:0006464 : protein modification process [18655 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
    - GO:0019637 : organophosphate metabolic process [3046 gene products]
    - - GO:0006644 : phospholipid metabolic process [2779 gene products]
      - GO:0006650 : glycerophospholipid metabolic process [1117 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0030384 : phosphoinositide metabolic process [801 gene products]
        
        GO:0006505 : GPI anchor metabolic process [394 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0008654 : phospholipid biosynthetic process [1500 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
    - GO:0044238 : primary metabolic process [141364 gene products]
    - - GO:0006629 : lipid metabolic process [12044 gene products]
      - GO:0044255 : cellular lipid metabolic process [9161 gene products]
        
        GO:0046486 : glycerolipid metabolic process [1411 gene products]
        
        GO:0045017 : glycerolipid biosynthetic process [749 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0006650 : glycerophospholipid metabolic process [1117 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0030384 : phosphoinositide metabolic process [801 gene products]
        
        GO:0006505 : GPI anchor metabolic process [394 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0006644 : phospholipid metabolic process [2779 gene products]
        
        GO:0006650 : glycerophospholipid metabolic process [1117 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0030384 : phosphoinositide metabolic process [801 gene products]
        
        GO:0006505 : GPI anchor metabolic process [394 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0008654 : phospholipid biosynthetic process [1500 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0008610 : lipid biosynthetic process [6688 gene products]
        
        GO:0045017 : glycerolipid biosynthetic process [749 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
        
        GO:0008654 : phospholipid biosynthetic process [1500 gene products]
        
        GO:0046474 : glycerophospholipid biosynthetic process [633 gene products]
        
        GO:0046489 : phosphoinositide biosynthetic process [441 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]
      - GO:0019538 : protein metabolic process [53200 gene products]
      - GO:0044267 : cellular protein metabolic process [43179 gene products]
        
        GO:0006464 : protein modification process [18655 gene products]
        
        GO:0006497 : protein amino acid lipidation [565 gene products]
        
        GO:0006506 : GPI anchor biosynthetic process [363 gene products]

External References

InterPro (12)

Pfam (9)

PIRSF (2)

SMART (1)

SM00780

SP_KW (1)

KW-0337