nucleotide-excision repair

Term information
Term lineage
External references
454 gene product associations

Term Information

Accession

GO:0006289

Ontology

biological process

Synonyms

related: intrastrand cross-link repair

narrow: interstrand crosslink repair

exact: NER

exact: pyrimidine-dimer repair, DNA damage excision

alt_id: GO:0045001

Definition

A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). [source: PMID:10197977]

Comment

Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair.

Subset

Unavailable

Community

There have been 0 comments for this term. If you would like to view or participate in the community annotation, please continue to the GONUTS page.

Term Lineage

Switch to viewing term parents, siblings and children

Filter tree view: Filter Gene Product Counts
Data source
Species

View Options
Tree view Full Compact

Actions...
Last action: Reset the tree
Graphical View
View in tree browser
Download...
OBO
RDF-XML
GraphViz dot

all : all [353918 gene products]
- GO:0008150 : biological_process [252790 gene products]
- - GO:0009987 : cellular process [140284 gene products]
  - - GO:0051716 : cellular response to stimulus [7985 gene products]
    - - GO:0033554 : cellular response to stress [5989 gene products]
      - GO:0034984 : cellular response to DNA damage stimulus [3652 gene products]
        
        GO:0006281 : DNA repair [3203 gene products]
        
        GO:0006289 : nucleotide-excision repair [454 gene products]
  - GO:0008152 : metabolic process [114209 gene products]
  - - GO:0006807 : nitrogen compound metabolic process [53186 gene products]
    - - GO:0006139 : nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [44302 gene products]
      - GO:0006259 : DNA metabolic process [9761 gene products]
        
        GO:0006281 : DNA repair [3203 gene products]
        
        GO:0006289 : nucleotide-excision repair [454 gene products]
    - GO:0044238 : primary metabolic process [94552 gene products]
    - - GO:0006139 : nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [44302 gene products]
      - GO:0006259 : DNA metabolic process [9761 gene products]
        
        GO:0006281 : DNA repair [3203 gene products]
        
        GO:0006289 : nucleotide-excision repair [454 gene products]
  - GO:0050896 : response to stimulus [29442 gene products]
  - - GO:0051716 : cellular response to stimulus [7985 gene products]
    - - GO:0033554 : cellular response to stress [5989 gene products]
      - GO:0034984 : cellular response to DNA damage stimulus [3652 gene products]
        
        GO:0006281 : DNA repair [3203 gene products]
        
        GO:0006289 : nucleotide-excision repair [454 gene products]
    - GO:0006950 : response to stress [15524 gene products]
    - - GO:0033554 : cellular response to stress [5989 gene products]
      - GO:0034984 : cellular response to DNA damage stimulus [3652 gene products]
        
        GO:0006281 : DNA repair [3203 gene products]
        
        GO:0006289 : nucleotide-excision repair [454 gene products]
      - GO:0006974 : response to DNA damage stimulus [3935 gene products]
      - GO:0034984 : cellular response to DNA damage stimulus [3652 gene products]
        
        GO:0006281 : DNA repair [3203 gene products]
        
        GO:0006289 : nucleotide-excision repair [454 gene products]

External References

HAMAP (3)

InterPro (21)

JCVI_TIGRFAMS (7)

Pfam (14)

PRINTS (3)

PROSITE (5)

Reactome (22)