tricarboxylic acid cycle

Term information
Term lineage
External references
22 gene product associations

Term Information

Accession

GO:0006099

Ontology

biological process

Synonyms

exact: citric acid cycle

exact: Krebs cycle

exact: TCA cycle

Definition

A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. [source: ISBN:0198506732]

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all : all [18608 gene products]
- GO:0008150 : biological_process [15006 gene products]
- - GO:0009987 : cellular process [12538 gene products]
  - - GO:0044237 : cellular metabolic process [7300 gene products]
    - - GO:0044248 : cellular catabolic process [1186 gene products]
      - GO:0051187 : cofactor catabolic process [30 gene products]
        
        GO:0009109 : coenzyme catabolic process [25 gene products]
        
        GO:0046356 : acetyl-CoA catabolic process [22 gene products]
        
        GO:0006099 : tricarboxylic acid cycle [22 gene products]
      - GO:0051186 : cofactor metabolic process [198 gene products]
      - GO:0006732 : coenzyme metabolic process [153 gene products]
        
        GO:0006084 : acetyl-CoA metabolic process [30 gene products]
        
        GO:0046356 : acetyl-CoA catabolic process [22 gene products]
        
        GO:0006099 : tricarboxylic acid cycle [22 gene products]
        
        GO:0009109 : coenzyme catabolic process [25 gene products]
        
        GO:0046356 : acetyl-CoA catabolic process [22 gene products]
        
        GO:0006099 : tricarboxylic acid cycle [22 gene products]
        
        GO:0051187 : cofactor catabolic process [30 gene products]
        
        GO:0009109 : coenzyme catabolic process [25 gene products]
        
        GO:0046356 : acetyl-CoA catabolic process [22 gene products]
        
        GO:0006099 : tricarboxylic acid cycle [22 gene products]
      - GO:0006091 : generation of precursor metabolites and energy [331 gene products]
      - GO:0015980 : energy derivation by oxidation of organic compounds [160 gene products]
        
        GO:0045333 : cellular respiration [100 gene products]
        
        GO:0009060 : aerobic respiration [34 gene products]
        
        GO:0006099 : tricarboxylic acid cycle [22 gene products]
  - GO:0008152 : metabolic process [8526 gene products]
  - - GO:0009056 : catabolic process [1354 gene products]
    - - GO:0044248 : cellular catabolic process [1186 gene products]
      - GO:0051187 : cofactor catabolic process [30 gene products]
        
        GO:0009109 : coenzyme catabolic process [25 gene products]
        
        GO:0046356 : acetyl-CoA catabolic process [22 gene products]
        
        GO:0006099 : tricarboxylic acid cycle [22 gene products]
    - GO:0044237 : cellular metabolic process [7300 gene products]
    - - GO:0044248 : cellular catabolic process [1186 gene products]
      - GO:0051187 : cofactor catabolic process [30 gene products]
        
        GO:0009109 : coenzyme catabolic process [25 gene products]
        
        GO:0046356 : acetyl-CoA catabolic process [22 gene products]
        
        GO:0006099 : tricarboxylic acid cycle [22 gene products]
      - GO:0051186 : cofactor metabolic process [198 gene products]
      - GO:0006732 : coenzyme metabolic process [153 gene products]
        
        GO:0006084 : acetyl-CoA metabolic process [30 gene products]
        
        GO:0046356 : acetyl-CoA catabolic process [22 gene products]
        
        GO:0006099 : tricarboxylic acid cycle [22 gene products]
        
        GO:0009109 : coenzyme catabolic process [25 gene products]
        
        GO:0046356 : acetyl-CoA catabolic process [22 gene products]
        
        GO:0006099 : tricarboxylic acid cycle [22 gene products]
        
        GO:0051187 : cofactor catabolic process [30 gene products]
        
        GO:0009109 : coenzyme catabolic process [25 gene products]
        
        GO:0046356 : acetyl-CoA catabolic process [22 gene products]
        
        GO:0006099 : tricarboxylic acid cycle [22 gene products]
      - GO:0006091 : generation of precursor metabolites and energy [331 gene products]
      - GO:0015980 : energy derivation by oxidation of organic compounds [160 gene products]
        
        GO:0045333 : cellular respiration [100 gene products]
        
        GO:0009060 : aerobic respiration [34 gene products]
        
        GO:0006099 : tricarboxylic acid cycle [22 gene products]

External References

COG (1)

C

GenProtEC (1)

1.3.4

HAMAP (9)

InterPro (22)

JCVI_EGAD (1)

energy/TCA

JCVI_TIGRFAMS (23)

MetaCyc (3)

MIPS_funcat (1)

02.10

MultiFun (1)

1.3.4

Pfam (7)

PIRSF (4)

PRINTS (1)

PR00150

PROSITE (7)

Reactome (23)

SP_KW (1)

KW-0816

TIGR_role (1)

17065

Wikipedia (1)

Tricarboxylic_acid_cycle