Term Information

Accession

GO:0005834

Ontology

cellular component

Synonyms

related: heterotrimeric G-protein GTPase activity

narrow: heterotrimeric G-protein GTPase, alpha-subunit

narrow: heterotrimeric G-protein GTPase, beta-subunit

narrow: heterotrimeric G-protein GTPase, gamma-subunit

Definition

Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. [source: ISBN:0198547684]

Comment

See also the molecular function term 'G-protein coupled receptor activity ; GO:0004930'.

Subset

• Unavailable

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Term Lineage

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External References

EC (1)

• 3.6.5.1

InterPro (2)

• IPR001770
• IPR015898

Pfam (1)

• PF00631

PRINTS (1)

• PR00321

PROSITE (1)

• PS50058

SMART (1)

• SM00224

TIGR_role (1)

• 22530

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