membrane attack complex

Term information
Term lineage
External references
11 gene product associations

Term Information

Accession: GO:0005579
Ontology: cellular component
Synonyms: narrow: membrane attack complex protein alphaM chain; narrow: membrane attack complex protein beta2 chain; exact: MAC; exact: TCC; exact: terminal complement complex
Definition: A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow. [source: GOC:add, ISBN:0198547684, ISBN:068340007X, ISBN:0781735149]
Comment: None
Subset: None
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Term Lineage

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all : all [269974 gene products]
- GO:0005575 : cellular_component [206089 gene products]
- - GO:0005623 : cell [143382 gene products]
  - - GO:0044464 : cell part [143363 gene products]
    - - GO:0016020 : membrane [52459 gene products]
      - GO:0044425 : membrane part [33918 gene products]
        
        GO:0031224 : intrinsic to membrane [29683 gene products]
        
        GO:0016021 : integral to membrane [28770 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0046930 : pore complex [428 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0031226 : intrinsic to plasma membrane [2005 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0044459 : plasma membrane part [4812 gene products]
        
        GO:0031226 : intrinsic to plasma membrane [2005 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0005886 : plasma membrane [10904 gene products]
        
        GO:0044459 : plasma membrane part [4812 gene products]
        
        GO:0031226 : intrinsic to plasma membrane [2005 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
      - GO:0044425 : membrane part [33918 gene products]
      - GO:0031224 : intrinsic to membrane [29683 gene products]
        
        GO:0016021 : integral to membrane [28770 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0046930 : pore complex [428 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0031226 : intrinsic to plasma membrane [2005 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0044459 : plasma membrane part [4812 gene products]
        
        GO:0031226 : intrinsic to plasma membrane [2005 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
  - GO:0044464 : cell part [143363 gene products]
  - - GO:0016020 : membrane [52459 gene products]
    - - GO:0044425 : membrane part [33918 gene products]
      - GO:0031224 : intrinsic to membrane [29683 gene products]
        
        GO:0016021 : integral to membrane [28770 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0046930 : pore complex [428 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0031226 : intrinsic to plasma membrane [2005 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0044459 : plasma membrane part [4812 gene products]
        
        GO:0031226 : intrinsic to plasma membrane [2005 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
      - GO:0005886 : plasma membrane [10904 gene products]
      - GO:0044459 : plasma membrane part [4812 gene products]
        
        GO:0031226 : intrinsic to plasma membrane [2005 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
    - GO:0044425 : membrane part [33918 gene products]
    - - GO:0031224 : intrinsic to membrane [29683 gene products]
      - GO:0016021 : integral to membrane [28770 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0046930 : pore complex [428 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0031226 : intrinsic to plasma membrane [2005 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
      - GO:0044459 : plasma membrane part [4812 gene products]
      - GO:0031226 : intrinsic to plasma membrane [2005 gene products]
        
        GO:0005887 : integral to plasma membrane [1831 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
        
        GO:0005579 : membrane attack complex [11 gene products]
  - GO:0032991 : macromolecular complex [20319 gene products]
  - - GO:0043234 : protein complex [14521 gene products]
    - - GO:0046930 : pore complex [428 gene products]
      - GO:0005579 : membrane attack complex [11 gene products]

External References

SP_KW (1)

KW-0473

Wikipedia (1)

Complement_membrane_attack_complex