inward rectifier potassium channel activity

Term information
Term lineage
External references
78 gene product associations

Term Information

Accession

GO:0005242

Ontology

molecular function

Synonyms

exact: Kir channel activity

Definition

Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. [source: GOC:cb, GOC:mah, PMID:14977398]

Comment

None

Subset

Unavailable

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all : all [269974 gene products]
- GO:0003674 : molecular_function [183428 gene products]
- - GO:0005215 : transporter activity [9997 gene products]
  - - GO:0022892 : substrate-specific transporter activity [7489 gene products]
    - - GO:0022891 : substrate-specific transmembrane transporter activity [6398 gene products]
      - GO:0015075 : ion transmembrane transporter activity [5047 gene products]
        
        GO:0008324 : cation transmembrane transporter activity [3700 gene products]
        
        GO:0046873 : metal ion transmembrane transporter activity [1907 gene products]
        
        GO:0005261 : cation channel activity [1244 gene products]
        
        GO:0005267 : potassium channel activity [655 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0005216 : ion channel activity [1958 gene products]
        
        GO:0005261 : cation channel activity [1244 gene products]
        
        GO:0005267 : potassium channel activity [655 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0015276 : ligand-gated ion channel activity [599 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0005244 : voltage-gated ion channel activity [864 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0022838 : substrate-specific channel activity [2024 gene products]
        
        GO:0005216 : ion channel activity [1958 gene products]
        
        GO:0005261 : cation channel activity [1244 gene products]
        
        GO:0005267 : potassium channel activity [655 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0015276 : ligand-gated ion channel activity [599 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0005244 : voltage-gated ion channel activity [864 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
    - GO:0022857 : transmembrane transporter activity [7693 gene products]
    - - GO:0022803 : passive transmembrane transporter activity [2134 gene products]
      - GO:0015267 : channel activity [2133 gene products]
        
        GO:0022836 : gated channel activity [1453 gene products]
        
        GO:0022834 : ligand-gated channel activity [599 gene products]
        
        GO:0015276 : ligand-gated ion channel activity [599 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0022832 : voltage-gated channel activity [866 gene products]
        
        GO:0005244 : voltage-gated ion channel activity [864 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0022838 : substrate-specific channel activity [2024 gene products]
        
        GO:0005216 : ion channel activity [1958 gene products]
        
        GO:0005261 : cation channel activity [1244 gene products]
        
        GO:0005267 : potassium channel activity [655 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0015276 : ligand-gated ion channel activity [599 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0005244 : voltage-gated ion channel activity [864 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
      - GO:0022891 : substrate-specific transmembrane transporter activity [6398 gene products]
      - GO:0015075 : ion transmembrane transporter activity [5047 gene products]
        
        GO:0008324 : cation transmembrane transporter activity [3700 gene products]
        
        GO:0046873 : metal ion transmembrane transporter activity [1907 gene products]
        
        GO:0005261 : cation channel activity [1244 gene products]
        
        GO:0005267 : potassium channel activity [655 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0005216 : ion channel activity [1958 gene products]
        
        GO:0005261 : cation channel activity [1244 gene products]
        
        GO:0005267 : potassium channel activity [655 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0015276 : ligand-gated ion channel activity [599 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0005244 : voltage-gated ion channel activity [864 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0022838 : substrate-specific channel activity [2024 gene products]
        
        GO:0005216 : ion channel activity [1958 gene products]
        
        GO:0005261 : cation channel activity [1244 gene products]
        
        GO:0005267 : potassium channel activity [655 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0015276 : ligand-gated ion channel activity [599 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]
        
        GO:0005244 : voltage-gated ion channel activity [864 gene products]
        
        GO:0022843 : voltage-gated cation channel activity [671 gene products]
        
        GO:0005249 : voltage-gated potassium channel activity [474 gene products]
        
        GO:0005242 : inward rectifier potassium channel activity [78 gene products]

External References

InterPro (9)

PRINTS (8)