Rho guanyl-nucleotide exchange factor activity

Term information
Term lineage
External references
524 gene product associations

Term Information

Accession: GO:0005089
Ontology: molecular function
Synonyms: exact: Rho guanine nucleotide exchange factor; exact: RhoGEF
Definition: Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. [source: GOC:mah]
Comment: None
Subset: None
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all : all [353918 gene products]
- GO:0003674 : molecular_function [267895 gene products]
- - GO:0030234 : enzyme regulator activity [5967 gene products]
  - - GO:0060589 : nucleoside-triphosphatase regulator activity [2852 gene products]
    - - GO:0030695 : GTPase regulator activity [2735 gene products]
      - GO:0005085 : guanyl-nucleotide exchange factor activity [1158 gene products]
        
        GO:0005088 : Ras guanyl-nucleotide exchange factor activity [621 gene products]
        
        GO:0005089 : Rho guanyl-nucleotide exchange factor activity [524 gene products]
        
        GO:0005083 : small GTPase regulator activity [1901 gene products]
        
        GO:0005088 : Ras guanyl-nucleotide exchange factor activity [621 gene products]
        
        GO:0005089 : Rho guanyl-nucleotide exchange factor activity [524 gene products]

External References

InterPro (2)

Pfam (2)

PROSITE (2)

Reactome (1)

11437

SMART (1)

SM00325