serine-type endopeptidase activity

Term information
Term lineage
External references
1018 gene product associations

Term Information

Accession

GO:0004252

Ontology

molecular function

Synonyms

related: blood coagulation factor activity

Definition

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [source: GOC:mah, ISBN:0716720094, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE]

Comment

None

Subset

Unavailable

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Term Lineage

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all : all [269974 gene products]
- GO:0003674 : molecular_function [183428 gene products]
- - GO:0003824 : catalytic activity [57076 gene products]
  - - GO:0016787 : hydrolase activity [20791 gene products]
    - - GO:0008233 : peptidase activity [4616 gene products]
      - GO:0070011 : peptidase activity, acting on L-amino acid peptides [4336 gene products]
        
        GO:0004175 : endopeptidase activity [2936 gene products]
        
        GO:0004252 : serine-type endopeptidase activity [1018 gene products]
        
        GO:0008236 : serine-type peptidase activity [1358 gene products]
        
        GO:0004252 : serine-type endopeptidase activity [1018 gene products]
      - GO:0017171 : serine hydrolase activity [1371 gene products]
      - GO:0008236 : serine-type peptidase activity [1358 gene products]
        
        GO:0004252 : serine-type endopeptidase activity [1018 gene products]

External References

EC (1)

3.4.21

HAMAP (4)

InterPro (68)

JCVI_TIGRFAMS (5)

Pfam (31)

PIRSF (20)

PRINTS (18)

ProDom (1)

PD021735

PROSITE (12)

Reactome (1)

1683

SMART (3)

SP_KW (1)

KW-0617