metalloendopeptidase activity

Term information
Term lineage
External references
754 gene product associations

Term Information

Accession

GO:0004222

Ontology

molecular function

Synonyms

exact: metalloendoprotease activity

exact: metalloendoproteinase activity

Definition

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [source: GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE]

Comment

None

Subset

Unavailable

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Term Lineage

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all : all [269974 gene products]
- GO:0003674 : molecular_function [183428 gene products]
- - GO:0003824 : catalytic activity [57076 gene products]
  - - GO:0016787 : hydrolase activity [20791 gene products]
    - - GO:0008233 : peptidase activity [4616 gene products]
      - GO:0070011 : peptidase activity, acting on L-amino acid peptides [4336 gene products]
        
        GO:0004175 : endopeptidase activity [2936 gene products]
        
        GO:0004222 : metalloendopeptidase activity [754 gene products]
        
        GO:0008237 : metallopeptidase activity [1310 gene products]
        
        GO:0004222 : metalloendopeptidase activity [754 gene products]

External References

EC (1)

3.4.24

HAMAP (6)

InterPro (44)

JCVI_TIGRFAMS (5)

Pfam (28)

PIRSF (7)

PRINTS (10)

ProDom (1)

PD016028

PROSITE (6)

Reactome (1)

1791

SMART (1)

SM00608