cysteine-type endopeptidase activity

Term information
Term lineage
External references
622 gene product associations

Term Information

Accession

GO:0004197

Ontology

molecular function

Synonyms

narrow: lysosomal cysteine-type endopeptidase

exact: thiol endopeptidase activity

Definition

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [source: GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE]

Comment

None

Subset

Unavailable

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Term Lineage

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all : all [353918 gene products]
- GO:0003674 : molecular_function [267895 gene products]
- - GO:0003824 : catalytic activity [91610 gene products]
  - - GO:0016787 : hydrolase activity [33490 gene products]
    - - GO:0008233 : peptidase activity [7315 gene products]
      - GO:0070011 : peptidase activity, acting on L-amino acid peptides [6714 gene products]
        
        GO:0008234 : cysteine-type peptidase activity [1220 gene products]
        
        GO:0004197 : cysteine-type endopeptidase activity [622 gene products]
        
        GO:0004175 : endopeptidase activity [4419 gene products]
        
        GO:0004197 : cysteine-type endopeptidase activity [622 gene products]

External References

EC (1)

3.4.22

InterPro (33)

Pfam (23)

PIRSF (4)

PRINTS (4)

ProDom (1)

PD003705

PROSITE (7)

Reactome (1)

4344