DNA topoisomerase type I activity

Term Information

Accession
GO:0003917
Ontology
molecular function
Synonyms
related: nicking-closing enzyme activity
related: omega-protein activity
related: relaxing enzyme activity
related: swivelase activity
related: untwisting enzyme activity
narrow: DNA topoisomerase I activity
exact: type I DNA topoisomerase activity
exact: type I topoisomerase activity
broad: deoxyribonucleate topoisomerase
broad: topoisomerase
Definition
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. [source: PMID:8811192]
Comment
Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity.
Subset
  • Unavailable
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External References

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