Term Information

Accession

GO:0001772

Ontology

cellular component

Synonyms

narrow: c-SMAC

exact: supramolecular activation cluster

Definition

An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. [source: GOC:mgi_curators, PMID:11244041, PMID:11376300]

Comment

None

Subset

None

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Term Lineage

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External References

Wikipedia (1)

• Immunological_synapse

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