nuclear mRNA splicing, via spliceosome

Term information
Term lineage
External references
938 gene product associations

Term Information

Accession: GO:0000398
Ontology: biological process
Synonyms: related: splicing AT-AC intron; related: splicing GT-AG intron; narrow: nuclear mRNA splicing via U12-type spliceosome; narrow: nuclear mRNA splicing via U2-type spliceosome; alt_id: GO:0006374; alt_id: GO:0006375; broad: mRNA splicing; broad: pre-mRNA splicing
Definition: The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. [source: GOC:krc, ISBN:0198506732, ISBN:0879695897]
Comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron.
Subset: None
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all : all [353918 gene products]
- GO:0008150 : biological_process [252790 gene products]
- - GO:0009987 : cellular process [140284 gene products]
  - - GO:0044237 : cellular metabolic process [86234 gene products]
    - - GO:0044260 : cellular macromolecule metabolic process [60422 gene products]
      - GO:0016070 : RNA metabolic process [24821 gene products]
        
        GO:0016071 : mRNA metabolic process [2828 gene products]
        
        GO:0006397 : mRNA processing [2252 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
        
        GO:0006396 : RNA processing [6135 gene products]
        
        GO:0006397 : mRNA processing [2252 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]
        
        GO:0000377 : RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [949 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
  - GO:0008152 : metabolic process [114209 gene products]
  - - GO:0044237 : cellular metabolic process [86234 gene products]
    - - GO:0044260 : cellular macromolecule metabolic process [60422 gene products]
      - GO:0016070 : RNA metabolic process [24821 gene products]
        
        GO:0016071 : mRNA metabolic process [2828 gene products]
        
        GO:0006397 : mRNA processing [2252 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
        
        GO:0006396 : RNA processing [6135 gene products]
        
        GO:0006397 : mRNA processing [2252 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]
        
        GO:0000377 : RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [949 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
    - GO:0043170 : macromolecule metabolic process [68932 gene products]
    - - GO:0044260 : cellular macromolecule metabolic process [60422 gene products]
      - GO:0016070 : RNA metabolic process [24821 gene products]
        
        GO:0016071 : mRNA metabolic process [2828 gene products]
        
        GO:0006397 : mRNA processing [2252 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
        
        GO:0006396 : RNA processing [6135 gene products]
        
        GO:0006397 : mRNA processing [2252 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]
        
        GO:0000377 : RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [949 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
      - GO:0010467 : gene expression [38606 gene products]
      - GO:0006396 : RNA processing [6135 gene products]
        
        GO:0006397 : mRNA processing [2252 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]
        
        GO:0000377 : RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [949 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
    - GO:0006807 : nitrogen compound metabolic process [53186 gene products]
    - - GO:0006139 : nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [44302 gene products]
      - GO:0016070 : RNA metabolic process [24821 gene products]
        
        GO:0016071 : mRNA metabolic process [2828 gene products]
        
        GO:0006397 : mRNA processing [2252 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
        
        GO:0006396 : RNA processing [6135 gene products]
        
        GO:0006397 : mRNA processing [2252 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]
        
        GO:0000377 : RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [949 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
    - GO:0044238 : primary metabolic process [94552 gene products]
    - - GO:0006139 : nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [44302 gene products]
      - GO:0016070 : RNA metabolic process [24821 gene products]
        
        GO:0016071 : mRNA metabolic process [2828 gene products]
        
        GO:0006397 : mRNA processing [2252 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
        
        GO:0006396 : RNA processing [6135 gene products]
        
        GO:0006397 : mRNA processing [2252 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]
        
        GO:0000377 : RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [949 gene products]
        
        GO:0000398 : nuclear mRNA splicing, via spliceosome [938 gene products]

External References

InterPro (7)

MIPS_funcat (1)

11.04.03

Pfam (5)

ProDom (1)

PD149576

Reactome (16)