RNA splicing, via transesterification reactions

Term information
Term lineage
External references
982 gene product associations

Term Information

Accession

GO:0000375

Ontology

biological process

Synonyms

related: pre-mRNA splicing factor activity

related: RNA splicing factor activity, transesterification mechanism

related: spliceosomal catalysis

alt_id: GO:0000385

alt_id: GO:0031202

Definition

Splicing of RNA via a series of two transesterification reactions. [source: GOC:krc]

Comment

Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism.

Subset

Unavailable

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all : all [353918 gene products]
- GO:0008150 : biological_process [252790 gene products]
- - GO:0009987 : cellular process [140284 gene products]
  - - GO:0044237 : cellular metabolic process [86234 gene products]
    - - GO:0044260 : cellular macromolecule metabolic process [60422 gene products]
      - GO:0016070 : RNA metabolic process [24821 gene products]
        
        GO:0006396 : RNA processing [6135 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]
  - GO:0008152 : metabolic process [114209 gene products]
  - - GO:0044237 : cellular metabolic process [86234 gene products]
    - - GO:0044260 : cellular macromolecule metabolic process [60422 gene products]
      - GO:0016070 : RNA metabolic process [24821 gene products]
        
        GO:0006396 : RNA processing [6135 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]
    - GO:0043170 : macromolecule metabolic process [68932 gene products]
    - - GO:0044260 : cellular macromolecule metabolic process [60422 gene products]
      - GO:0016070 : RNA metabolic process [24821 gene products]
        
        GO:0006396 : RNA processing [6135 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]
      - GO:0010467 : gene expression [38606 gene products]
      - GO:0006396 : RNA processing [6135 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]
    - GO:0006807 : nitrogen compound metabolic process [53186 gene products]
    - - GO:0006139 : nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [44302 gene products]
      - GO:0016070 : RNA metabolic process [24821 gene products]
        
        GO:0006396 : RNA processing [6135 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]
    - GO:0044238 : primary metabolic process [94552 gene products]
    - - GO:0006139 : nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [44302 gene products]
      - GO:0016070 : RNA metabolic process [24821 gene products]
        
        GO:0006396 : RNA processing [6135 gene products]
        
        GO:0008380 : RNA splicing [1868 gene products]
        
        GO:0000375 : RNA splicing, via transesterification reactions [982 gene products]

External References

Reactome (1)

160901