CAAX-protein geranylgeranyltransferase activity
Term Information
- Accession
- GO:0004662
- Ontology
- molecular function
- Synonyms
- related: protein geranylgeranyltransferase type I
- exact: geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity
- exact: geranylgeranyltransferase type I activity
- exact: GGTase-I activity
- exact: GGTaseI activity
- exact: type I protein geranyl-geranyltransferase activity
- Definition
- Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. [source:
EC:2.5.1.59, PMID:8621375]
- Comment
- None
- Subset
- None
- Community
- Unavailable
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[447044 gene products]
