Term Information [More information on necroptotic signaling pathway]

Accession
GO:0097527
Name
necroptotic signaling pathway
Ontology
biological_process
Synonyms
necroptosis signaling pathway, necroptotic signal transduction, necroptosis signaling, necroptotic signalling pathway
Definition
A series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered. Source: PMID:20823910, GOC:mtg_apoptosis
Comment
Gene products that may be annotated to this term include: 1) ligands such as TNF-alpha; 2) receptors such as TNFR (though care should be taken because TNF-alpha and TNFR may also be involved in non-necroptotic processes); 3) signaling molecules such as TNFR-associated death domain (TRADD), receptor-interacting protein kinase 1 (RIP1), cellular inhibitor of apoptosis 1 (cIAP1), cIAP2, TNFR-associated factor 2 (TRAF2) and TRAF5. Within the so-called complex I, RIP1 is polyubiquitinated by cIAPs, thereby providing a docking site for the recruitment of transforming growth factor beta (TGFbeta)-activated kinase 1 (TAK1), TAK1-binding protein 2 (TAB2) and TAB3 (which together deliver a pro-survival signal by activating the transcription factor NF-kB). In some pathophysiological and experimental settings, and in particular when caspase-8 is absent or when caspases are inhibited by pharmacological agents, cylindromatosis (CYLD)-deubiquitinated RIP1 engage in physical and functional interactions with its homolog RIP3, ultimately activating the execution of necrotic cell death. (The pathway downstream of RIPK3 remains largely unknown, although ROS generation, calcium overload, and the opening of the mitochondrial permeability transition pore have been implicated (PMID:22265414)). A necroptotic signaling pathway may also be induced by alkylating DNA damage (possibly by the overactivation of poly(ADP-ribose) polymerase 1, PARP1).
History
See term history for GO:0097527 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0097527 from QuickGO

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Ancestors of necroptotic signaling pathway (GO:0097527)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
necroptotic signaling pathway [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
necroptotic signaling pathway [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) death (GO:0016265)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
necroptotic signaling pathway [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) cell death (GO:0008219)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) necrotic cell death (GO:0070265)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) programmed cell death (GO:0012501)
necroptotic signaling pathway [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) programmed necrotic cell death (GO:0097300)
necroptotic signaling pathway [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
necroptotic signaling pathway [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
necroptotic signaling pathway [part_of relation] part_of  necroptotic process (GO:0070266)
necroptotic signaling pathway [is_a relation] is_a  signal transduction (GO:0007165)

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