Term Information [More information on GAIT complex]

Accession
GO:0097452
Name
GAIT complex
Ontology
cellular_component
Synonyms
IFN-gamma-activated inhibitor of translation complex, gamma interferon-activated inhibitor of translation complex
Definition
A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. Source: PMID:23071094, GOC:br, PMID:15479637
Comment
None
History
See term history for GO:0097452 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0097452 from QuickGO

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Ancestors of GAIT complex (GO:0097452)
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GAIT complex [Inferred is_a relation] is_a (inferred) cellular_component (GO:0005575)
GAIT complex [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
GAIT complex [is_a relation] is_a  protein complex (GO:0043234)

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