AmiGO 2: Term Details for "GAIT complex" (GO:0097452)

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Term Information

Accession: GO:0097452
Name: GAIT complex
Ontology: cellular_component
Synonyms: IFN-gamma-activated inhibitor of translation complex, gamma interferon-activated inhibitor of translation complex
Alternate IDs: None
Definition: A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. Source: PMID:23071094, GOC:br, PMID:15479637
Comment: None
History: See term history for GO:0097452 at QuickGO
Subset: None
Related: Link to all genes and gene products annotated to GAIT complex.; Link to all direct and indirect annotations to GAIT complex.; Link to all direct and indirect annotations download (limited to first 10,000) for GAIT complex.

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Parents of GAIT complex (GO:0097452)

subject	relation	object
GAIT complex	is_a	protein complex (GO:0043234)

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