Term Information [More information on neurofibrillary tangle]

Accession
GO:0097418
Name
neurofibrillary tangle
Ontology
cellular_component
Synonyms
flame-shaped neurofibrillary tangle, star-shaped neurofibrillary tangle
Definition
Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star. Source: NIF_Subcellular:nlx_subcell_20090201, NIF_Subcellular:sao2409833926, NIF_Subcellular:nlx_subcell_20090202
Comment
Neurofibrillary tangles have been found in aging population; their formation is increased in Alzheimer's disease patients (and in other neurological diseases) compared to normal controls (see PMID:848276 and PMID:8584267).
History
See term history for GO:0097418 at QuickGO
Subset
None
Community
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Feedback
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Contacting server...
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Graph of GO:0097418 from QuickGO

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Ancestors of neurofibrillary tangle (GO:0097418)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) anatomical entity (UBERON:0001062)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) material anatomical entity (CARO:0000006)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) material anatomical entity (UBERON:0000465)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) anatomical structure (CARO:0000003)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) anatomical structure (UBERON:0000061)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) cell (CL:0000000)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) multicellular anatomical structure (UBERON:0010000)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) multicellular organism (UBERON:0000468)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) native cell (CL:0000003)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) anatomical system (UBERON:0000467)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) eukaryotic cell (CL:0000255)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) animal cell (CL:0000548)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) electrically active cell (CL:0000211)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) nervous system (UBERON:0001016)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) somatic cell (CL:0002371)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) electrically responsive cell (CL:0000393)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) electrically signaling cell (CL:0000404)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) neural cell (CL:0002319)
neurofibrillary tangle [Inferred is_a relation] is_a (inferred) intracellular part (GO:0044424)
neurofibrillary tangle [Inferred part_of relation] part_of (inferred) neuron (CL:0000540)
neurofibrillary tangle [is_a relation] is_a  inclusion body (GO:0016234)
neurofibrillary tangle [is_a relation] is_a  neuron part (GO:0097458)

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