Term Information [More information on hypoxia-inducible factor-1alpha signaling pathway]

Accession
GO:0097411
Name
hypoxia-inducible factor-1alpha signaling pathway
Ontology
biological_process
Synonyms
HIF1alpha pathway, hypoxia-inducible factor signaling, hypoxia-inducible factor-1alpha signalling pathway
Definition
A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia. Source: GOC:jc, GOC:bf, http://www.sabiosciences.com/pathway.php?sn=HIF1Alpha_Pathway
Comment
None
History
See term history for GO:0097411 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0097411 from QuickGO

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Ancestors of hypoxia-inducible factor-1alpha signaling pathway (GO:0097411)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
hypoxia-inducible factor-1alpha signaling pathway [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
hypoxia-inducible factor-1alpha signaling pathway [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) response to abiotic stimulus (GO:0009628)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) response to chemical (GO:0042221)
hypoxia-inducible factor-1alpha signaling pathway [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to chemical stimulus (GO:0070887)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) response to oxygen levels (GO:0070482)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to oxygen levels (GO:0071453)
hypoxia-inducible factor-1alpha signaling pathway [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) response to decreased oxygen levels (GO:0036293)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) response to stress (GO:0006950)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to decreased oxygen levels (GO:0036294)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to stress (GO:0033554)
hypoxia-inducible factor-1alpha signaling pathway [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) response to hypoxia (GO:0001666)
hypoxia-inducible factor-1alpha signaling pathway [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
hypoxia-inducible factor-1alpha signaling pathway [part_of relation] part_of  cellular response to hypoxia (GO:0071456)
hypoxia-inducible factor-1alpha signaling pathway [is_a relation] is_a  signal transduction (GO:0007165)
Children of hypoxia-inducible factor-1alpha signaling pathway (GO:0097411)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of hypoxia-inducible factor-1alpha signaling pathway (GO:1902072) [negatively_regulates relation] negatively_regulates  hypoxia-inducible factor-1alpha signaling pathway
positive regulation of hypoxia-inducible factor-1alpha signaling pathway (GO:1902073) [positively_regulates relation] positively_regulates  hypoxia-inducible factor-1alpha signaling pathway
regulation of hypoxia-inducible factor-1alpha signaling pathway (GO:1902071) [regulates relation] regulates  hypoxia-inducible factor-1alpha signaling pathway
None.