Term Information [More information on ripoptosome]

Accession
GO:0097342
Name
ripoptosome
Ontology
cellular_component
Synonyms
necrosome, TNFR1 complex II, Tnfr1-CII
Definition
A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. Source: PMID:22265414, PMID:22274400, GOC:bhm, GOC:mtg_apoptosis
Comment
It has been shown that receptor-mediated necroptotic signaling pathway requires assembly of a ripoptosome protein complex consisting of caspase-8, caspase-10, Fas-associated death domain protein (FADD), casp8 and FADD-like apoptosis regulator (CFLAR) as well as the two receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (PMID:21737330). Optionally, depending on the receptor activated, this complex may contain TLR3 adaptor protein TRIF (PMID:21737330).
History
See term history for GO:0097342 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0097342 from QuickGO

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Ancestors of ripoptosome (GO:0097342)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ripoptosome [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
ripoptosome [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
ripoptosome [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
ripoptosome [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
ripoptosome [Inferred part_of relation] part_of (inferred) intracellular part (GO:0044424)
ripoptosome [Inferred capable_of part of relation] capable_of part of (inferred) biological_process (GO:0008150)
ripoptosome [Inferred part_of relation] part_of (inferred) cytoplasm (GO:0005737)
ripoptosome [Inferred part_of relation] part_of (inferred) cytoplasmic part (GO:0044444)
ripoptosome [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
ripoptosome [Inferred capable_of part of relation] capable_of part of (inferred) metabolic process (GO:0008152)
ripoptosome [Inferred capable_of relation] capable_of (inferred) molecular_function (GO:0003674)
ripoptosome [Inferred capable_of relation] capable_of (inferred) catalytic activity (GO:0003824)
ripoptosome [part_of relation] part_of  cytosol (GO:0005829)
ripoptosome [Inferred is_a relation] is_a (inferred) protein complex (GO:0043234)
ripoptosome [is_a relation] is_a  catalytic complex (GO:1902494)
ripoptosome [is_a relation] is_a  cytosolic part (GO:0044445)

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