Term Information [More information on intrinsic apoptotic signaling pathway]

Accession
GO:0097193
Name
intrinsic apoptotic signaling pathway
Ontology
biological_process
Synonyms
alt. id: GO:0008629
intrinsic apoptotic pathway, intrinsic apoptotic signalling pathway, mitochondrial-mediated apoptotic pathway, induction of apoptosis by intracellular signals, intrinsic apoptosis
Definition
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). Source: PMID:18852119, PMID:17340152, GOC:mtg_apoptosis, PMID:11919192, GOC:yaf
Comment
The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595.
History
See term history for GO:0097193 at QuickGO
Subset
None
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
Contact the GO Helpdesk if you find mistakes or have concerns about the data you find here.
Contacting server...
View this term in QuickGO.

Graph of GO:0097193 from QuickGO

Additional external viewing options
Additional internal viewing options
Ancestors of intrinsic apoptotic signaling pathway (GO:0097193)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
intrinsic apoptotic signaling pathway [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
intrinsic apoptotic signaling pathway [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
intrinsic apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
intrinsic apoptotic signaling pathway [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
intrinsic apoptotic signaling pathway [Inferred occurs_in relation] occurs_in (inferred) cellular_component (GO:0005575)
intrinsic apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) death (GO:0016265)
intrinsic apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
intrinsic apoptotic signaling pathway [Inferred occurs_in relation] occurs_in (inferred) cell (GO:0005623)
intrinsic apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) cell death (GO:0008219)
intrinsic apoptotic signaling pathway [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
intrinsic apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
intrinsic apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
intrinsic apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
intrinsic apoptotic signaling pathway [Inferred occurs_in relation] occurs_in (inferred) cell part (GO:0044464)
intrinsic apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
intrinsic apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) programmed cell death (GO:0012501)
intrinsic apoptotic signaling pathway [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
intrinsic apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
intrinsic apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) apoptotic process (GO:0006915)
intrinsic apoptotic signaling pathway [Inferred occurs_in relation] occurs_in (inferred) intracellular (GO:0005622)
intrinsic apoptotic signaling pathway [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
intrinsic apoptotic signaling pathway [is_a relation] is_a  apoptotic signaling pathway (GO:0097190)
intrinsic apoptotic signaling pathway [is_a relation] is_a  intracellular signal transduction (GO:0035556)
Children of intrinsic apoptotic signaling pathway (GO:0097193)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
intrinsic apoptotic signaling pathway by p53 class mediator (GO:0072332) [is_a relation] is_a  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630) [is_a relation] is_a  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059) [is_a relation] is_a  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to hypoxia (GO:1990144) [is_a relation] is_a  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to nitrosative stress (GO:1990442) [is_a relation] is_a  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to osmotic stress (GO:0008627) [is_a relation] is_a  intrinsic apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631) [is_a relation] is_a  intrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway (GO:2001243) [negatively_regulates relation] negatively_regulates  intrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway (GO:2001244) [positively_regulates relation] positively_regulates  intrinsic apoptotic signaling pathway
regulation of intrinsic apoptotic signaling pathway (GO:2001242) [regulates relation] regulates  intrinsic apoptotic signaling pathway