Term Information [More information on extrinsic apoptotic signaling pathway in absence of ligand]

Accession
GO:0097192
Name
extrinsic apoptotic signaling pathway in absence of ligand
Ontology
biological_process
Synonyms
extrinsic apoptotic signalling pathway in absence of ligand, dependence receptor signaling pathway, extrinsic apoptosis in absence of ligand
Definition
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. Source: PMID:20816705, PMID:15044679, GOC:mtg_apoptosis
Comment
For dependence receptors, absence of a ligand or withdrawal of a ligand from a receptor acts as a signal. An example of 'extrinsic apoptotic signaling pathway in absence of ligand' is withdrawal of a growth factor such as NGF, even if traditionally apoptosis induced via growth factor withdrawal has been classified as an instance of intrinsic apoptosis. See an example in PMID:19767770. Ligands whose withdrawal or absence induce apoptosis should be annotated to GO:2001239 'regulation of extrinsic apoptotic signaling pathway in absence of ligand', rather than to the pathway term itself. Examples of gene products that may be annotated to GO:0097192 'extrinsic apoptotic signaling pathway in absence of ligand' include dependence receptors such as DCC or UNC5B, which relay lethal signals in the absence of their ligand (netrin-1). In the case of DCC and UNC5B, the signaling proceeds through the assembly of a DRAL- and TUCAN- (or NLRP1-) containing caspase-9-activating complex or by the dephosphorylation-mediated activation of death-associated protein kinase 1 (DAPK1) by UNC5B-bound protein phosphatase 2A (PP2A), respectively. DAPK1 can mediate the direct activation of executioner caspases or favor MOMP (reviewed in PMID:21760595). Also see PMID:21172653 (annotations to UNC5B and PR65beta, UniProt symbols O08722, PPP2R1B and P30154).
History
See term history for GO:0097192 at QuickGO
Subset
None
Community
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Graph of GO:0097192 from QuickGO

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Ancestors of extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
extrinsic apoptotic signaling pathway in absence of ligand [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred part_of relation] part_of (inferred) death (GO:0016265)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred part_of relation] part_of (inferred) cell death (GO:0008219)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred part_of relation] part_of (inferred) programmed cell death (GO:0012501)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred part_of relation] part_of (inferred) apoptotic process (GO:0006915)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred is_a relation] is_a (inferred) apoptotic signaling pathway (GO:0097190)
extrinsic apoptotic signaling pathway in absence of ligand [Inferred is_a relation] is_a (inferred) cell surface receptor signaling pathway (GO:0007166)
extrinsic apoptotic signaling pathway in absence of ligand [is_a relation] is_a  extrinsic apoptotic signaling pathway (GO:0097191)
extrinsic apoptotic signaling pathway in absence of ligand [is_a relation] is_a  signal transduction in absence of ligand (GO:0038034)
Children of extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001240) [negatively_regulates relation] negatively_regulates  extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241) [positively_regulates relation] positively_regulates  extrinsic apoptotic signaling pathway in absence of ligand
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239) [regulates relation] regulates  extrinsic apoptotic signaling pathway in absence of ligand
None.