Term Information [More information on apoptotic signaling pathway]

Accession
GO:0097190
Name
apoptotic signaling pathway
Ontology
biological_process
Synonyms
alt. id: GO:0008624
apoptotic signalling pathway, induction of apoptosis by extracellular signals
Definition
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered. Source: GOC:mtg_apoptosis
Comment
This term can be used to annotate gene products involved in apoptotic events happening downstream of the cross-talk point between the extrinsic and intrinsic apoptotic pathways. The cross-talk starts when caspase-8 cleaves Bid and truncated Bid interacts with mitochondria. From this point on it is not possible to distinguish between extrinsic and intrinsic pathways.
History
See term history for GO:0097190 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0097190 from QuickGO

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Ancestors of apoptotic signaling pathway (GO:0097190)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
apoptotic signaling pathway [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
apoptotic signaling pathway [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
apoptotic signaling pathway [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) cell death (GO:0008219)
apoptotic signaling pathway [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) programmed cell death (GO:0012501)
apoptotic signaling pathway [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
apoptotic signaling pathway [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
apoptotic signaling pathway [part_of relation] part_of  apoptotic process (GO:0006915)
apoptotic signaling pathway [is_a relation] is_a  signal transduction (GO:0007165)
Children of apoptotic signaling pathway (GO:0097190)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:0097296) [part_of relation] part_of  apoptotic signaling pathway
apoptosome assembly (GO:0097314) [part_of relation] part_of  apoptotic signaling pathway
cysteine-type endopeptidase activity involved in apoptotic signaling pathway (GO:0097199) [part_of relation] part_of  apoptotic signaling pathway
extrinsic apoptotic signaling pathway (GO:0097191) [is_a relation] is_a  apoptotic signaling pathway
granzyme-mediated apoptotic signaling pathway (GO:0008626) [is_a relation] is_a  apoptotic signaling pathway
hormone-mediated apoptotic signaling pathway (GO:0008628) [is_a relation] is_a  apoptotic signaling pathway
intrinsic apoptotic signaling pathway (GO:0097193) [is_a relation] is_a  apoptotic signaling pathway
mitochondrial outer membrane permeabilization (GO:0097345) [part_of relation] part_of  apoptotic signaling pathway
negative regulation of apoptotic signaling pathway (GO:2001234) [negatively_regulates relation] negatively_regulates  apoptotic signaling pathway
positive regulation of apoptotic signaling pathway (GO:2001235) [positively_regulates relation] positively_regulates  apoptotic signaling pathway
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (GO:0001844) [part_of relation] part_of  apoptotic signaling pathway
regulation of apoptotic signaling pathway (GO:2001233) [regulates relation] regulates  apoptotic signaling pathway
release of cytochrome c from mitochondria (GO:0001836) [part_of relation] part_of  apoptotic signaling pathway