Term Information [More information on negative regulation of release of cytochrome c from mitochondria]

Accession
GO:0090201
Name
negative regulation of release of cytochrome c from mitochondria
Ontology
biological_process
Synonyms
None
Definition
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. Source: GOC:dph, GOC:tb, GOC:mtg_apoptosis, GOC:BHF
Comment
The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that directly and negatively regulate this process.
History
See term history for GO:0090201 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0090201 from QuickGO

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Ancestors of negative regulation of release of cytochrome c from mitochondria (GO:0090201)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) biological_process (GO:0008150)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) biological regulation (GO:0065007)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular process (GO:0009987)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) single-organism process (GO:0044699)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular component organization or biogenesis (GO:0071840)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) regulation of biological process (GO:0050789)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) single-organism cellular process (GO:0044763)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) cell death (GO:0008219)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular component organization (GO:0016043)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) negative regulation of biological process (GO:0048519)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) regulation of cellular process (GO:0050794)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) response to stimulus (GO:0050896)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) signaling (GO:0023052)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) cell communication (GO:0007154)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular response to stimulus (GO:0051716)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) negative regulation of cellular process (GO:0048523)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) organelle organization (GO:0006996)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) programmed cell death (GO:0012501)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) regulation of cell death (GO:0010941)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) single organism signaling (GO:0044700)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) apoptotic process (GO:0006915)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) mitochondrion organization (GO:0007005)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) negative regulation of cell death (GO:0060548)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) regulation of cell communication (GO:0010646)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) regulation of cellular component organization (GO:0051128)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) regulation of programmed cell death (GO:0043067)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) regulation of response to stimulus (GO:0048583)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) regulation of signaling (GO:0023051)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) signal transduction (GO:0007165)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) apoptotic mitochondrial changes (GO:0008637)
negative regulation of release of cytochrome c from mitochondria [Inferred negatively_regulates relation] negatively_regulates (inferred) apoptotic signaling pathway (GO:0097190)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) negative regulation of cell communication (GO:0010648)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) negative regulation of cellular component organization (GO:0051129)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) negative regulation of programmed cell death (GO:0043069)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) negative regulation of response to stimulus (GO:0048585)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) negative regulation of signaling (GO:0023057)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) regulation of apoptotic process (GO:0042981)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) regulation of organelle organization (GO:0033043)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) regulation of signal transduction (GO:0009966)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) negative regulation of apoptotic process (GO:0043066)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) negative regulation of organelle organization (GO:0010639)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) negative regulation of signal transduction (GO:0009968)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) regulation of apoptotic signaling pathway (GO:2001233)
negative regulation of release of cytochrome c from mitochondria [Inferred is_a relation] is_a (inferred) regulation of mitochondrion organization (GO:0010821)
negative regulation of release of cytochrome c from mitochondria [negatively_regulates relation] negatively_regulates  release of cytochrome c from mitochondria (GO:0001836)
negative regulation of release of cytochrome c from mitochondria [is_a relation] is_a  negative regulation of apoptotic signaling pathway (GO:2001234)
negative regulation of release of cytochrome c from mitochondria [is_a relation] is_a  negative regulation of mitochondrion organization (GO:0010823)
negative regulation of release of cytochrome c from mitochondria [is_a relation] is_a  regulation of release of cytochrome c from mitochondria (GO:0090199)

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