Term Information [More information on NLRP3 inflammasome complex]

Accession
GO:0072559
Name
NLRP3 inflammasome complex
Ontology
cellular_component
Synonyms
NALP3 inflammasome complex
Definition
A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. Source: GOC:vp, GOC:add, GOC:BHF, PMID:20303873
Comment
None
History
See term history for GO:0072559 at QuickGO
Subset
None
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
Contact the GO Helpdesk if you find mistakes or have concerns about the data you find here.
Contacting server...
View this term in QuickGO.

Graph of GO:0072559 from QuickGO

Additional external viewing options
Additional internal viewing options
Ancestors of NLRP3 inflammasome complex (GO:0072559)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
NLRP3 inflammasome complex [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) biological_process (GO:0008150)
NLRP3 inflammasome complex [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) biological regulation (GO:0065007)
NLRP3 inflammasome complex [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
NLRP3 inflammasome complex [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of biological process (GO:0050789)
NLRP3 inflammasome complex [Inferred related_to relation] related_to (inferred) response to stimulus (GO:0050896)
NLRP3 inflammasome complex [Inferred part_of relation] part_of (inferred) intracellular part (GO:0044424)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of response to stimulus (GO:0048583)
NLRP3 inflammasome complex [Inferred related_to relation] related_to (inferred) response to stress (GO:0006950)
NLRP3 inflammasome complex [Inferred part_of relation] part_of (inferred) cytoplasm (GO:0005737)
NLRP3 inflammasome complex [Inferred related_to relation] related_to (inferred) defense response (GO:0006952)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) positive regulation of biological process (GO:0048518)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of response to stress (GO:0080134)
NLRP3 inflammasome complex [Inferred related_to relation] related_to (inferred) response to external stimulus (GO:0009605)
NLRP3 inflammasome complex [Inferred related_to relation] related_to (inferred) response to wounding (GO:0009611)
NLRP3 inflammasome complex [Inferred part_of relation] part_of (inferred) cytoplasmic part (GO:0044444)
NLRP3 inflammasome complex [Inferred related_to relation] related_to (inferred) inflammatory response (GO:0006954)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) positive regulation of response to stimulus (GO:0048584)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of defense response (GO:0031347)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of response to external stimulus (GO:0032101)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of response to wounding (GO:1903034)
NLRP3 inflammasome complex [Inferred part_of relation] part_of (inferred) cytosol (GO:0005829)
NLRP3 inflammasome complex [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) positive regulation of defense response (GO:0031349)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) positive regulation of response to external stimulus (GO:0032103)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) positive regulation of response to wounding (GO:1903036)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of inflammatory response (GO:0050727)
NLRP3 inflammasome complex [Inferred is_a relation] is_a (inferred) cytosolic part (GO:0044445)
NLRP3 inflammasome complex [Inferred capable_of part of relation] capable_of part of (inferred) positive regulation of inflammatory response (GO:0050729)
NLRP3 inflammasome complex [is_a relation] is_a  protein complex (GO:0043234)
NLRP3 inflammasome complex [is_a relation] is_a  inflammasome complex (GO:0061702)

This term has no children.

None.