Term Information [More information on core mediator complex]

Accession
GO:0070847
Name
core mediator complex
Ontology
cellular_component
Synonyms
C mediator complex, S mediator complex
Definition
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. Source: PMID:11454195, PMID:16168358, PMID:17870225
Comment
None
History
See term history for GO:0070847 at QuickGO
Subset
None
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
Contact the GO Helpdesk if you find mistakes or have concerns about the data you find here.
Contacting server...
View this term in QuickGO.

Graph of GO:0070847 from QuickGO

Additional external viewing options
Additional internal viewing options
Ancestors of core mediator complex (GO:0070847)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) biological_process (GO:0008150)
core mediator complex [Inferred capable_of relation] capable_of (inferred) cellular process (GO:0009987)
core mediator complex [Inferred capable_of relation] capable_of (inferred) metabolic process (GO:0008152)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) biological regulation (GO:0065007)
core mediator complex [Inferred capable_of relation] capable_of (inferred) cellular metabolic process (GO:0044237)
core mediator complex [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) nitrogen compound metabolic process (GO:0006807)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) organic substance metabolic process (GO:0071704)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) biosynthetic process (GO:0009058)
core mediator complex [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular aromatic compound metabolic process (GO:0006725)
core mediator complex [Inferred capable_of relation] capable_of (inferred) cellular nitrogen compound metabolic process (GO:0034641)
core mediator complex [Inferred capable_of relation] capable_of (inferred) heterocycle metabolic process (GO:0046483)
core mediator complex [Inferred capable_of relation] capable_of (inferred) organic cyclic compound metabolic process (GO:1901360)
core mediator complex [Inferred capable_of relation] capable_of (inferred) primary metabolic process (GO:0044238)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of biological process (GO:0050789)
core mediator complex [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
core mediator complex [Inferred capable_of relation] capable_of (inferred) cellular biosynthetic process (GO:0044249)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) macromolecule metabolic process (GO:0043170)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) nucleobase-containing compound metabolic process (GO:0006139)
core mediator complex [Inferred capable_of relation] capable_of (inferred) organic substance biosynthetic process (GO:1901576)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of cellular process (GO:0050794)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of metabolic process (GO:0019222)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) aromatic compound biosynthetic process (GO:0019438)
core mediator complex [Inferred capable_of relation] capable_of (inferred) cellular macromolecule metabolic process (GO:0044260)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular nitrogen compound biosynthetic process (GO:0044271)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) heterocycle biosynthetic process (GO:0018130)
core mediator complex [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) molecular_function (GO:0003674)
core mediator complex [Inferred capable_of relation] capable_of (inferred) nucleic acid metabolic process (GO:0090304)
core mediator complex [Inferred capable_of relation] capable_of (inferred) organic cyclic compound biosynthetic process (GO:1901362)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of cellular metabolic process (GO:0031323)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of nitrogen compound metabolic process (GO:0051171)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of primary metabolic process (GO:0080090)
core mediator complex [Inferred related_to relation] related_to (inferred) catalytic activity (GO:0003824)
core mediator complex [Inferred part_of relation] part_of (inferred) intracellular part (GO:0044424)
core mediator complex [Inferred part_of relation] part_of (inferred) macromolecular complex (GO:0032991)
core mediator complex [Inferred capable_of relation] capable_of (inferred) macromolecule biosynthetic process (GO:0009059)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) nucleobase-containing compound biosynthetic process (GO:0034654)
core mediator complex [Inferred part_of relation] part_of (inferred) organelle (GO:0043226)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of biosynthetic process (GO:0009889)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of macromolecule metabolic process (GO:0060255)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of nucleobase-containing compound metabolic process (GO:0019219)
core mediator complex [Inferred capable_of relation] capable_of (inferred) RNA metabolic process (GO:0016070)
core mediator complex [Inferred part_of relation] part_of (inferred) intracellular organelle (GO:0043229)
core mediator complex [Inferred part_of relation] part_of (inferred) membrane-bounded organelle (GO:0043227)
core mediator complex [Inferred part_of relation] part_of (inferred) protein complex (GO:0043234)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of cellular biosynthetic process (GO:0031326)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of macromolecule biosynthetic process (GO:0010556)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of RNA metabolic process (GO:0051252)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) RNA biosynthetic process (GO:0032774)
core mediator complex [Inferred related_to relation] related_to (inferred) transferase activity (GO:0016740)
core mediator complex [Inferred part_of relation] part_of (inferred) catalytic complex (GO:1902494)
core mediator complex [Inferred capable_of relation] capable_of (inferred) cellular macromolecule biosynthetic process (GO:0034645)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) gene expression (GO:0010467)
core mediator complex [Inferred part_of relation] part_of (inferred) intracellular membrane-bounded organelle (GO:0043231)
core mediator complex [Inferred part_of relation] part_of (inferred) membrane-enclosed lumen (GO:0031974)
core mediator complex [Inferred capable_of relation] capable_of (inferred) nucleic acid-templated transcription (GO:0097659)
core mediator complex [Inferred part_of relation] part_of (inferred) organelle part (GO:0044422)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of RNA biosynthetic process (GO:2001141)
core mediator complex [Inferred related_to relation] related_to (inferred) transferase activity, transferring phosphorus-containing groups (GO:0016772)
core mediator complex [Inferred part_of relation] part_of (inferred) intracellular organelle part (GO:0044446)
core mediator complex [Inferred related_to relation] related_to (inferred) nucleotidyltransferase activity (GO:0016779)
core mediator complex [Inferred part_of relation] part_of (inferred) nucleus (GO:0005634)
core mediator complex [Inferred part_of relation] part_of (inferred) organelle lumen (GO:0043233)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of cellular macromolecule biosynthetic process (GO:2000112)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of gene expression (GO:0010468)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of nucleic acid-templated transcription (GO:1903506)
core mediator complex [Inferred capable_of relation] capable_of (inferred) transcription, DNA-templated (GO:0006351)
core mediator complex [Inferred part_of relation] part_of (inferred) transferase complex (GO:1990234)
core mediator complex [Inferred part_of relation] part_of (inferred) intracellular organelle lumen (GO:0070013)
core mediator complex [Inferred part_of relation] part_of (inferred) nuclear part (GO:0044428)
core mediator complex [Inferred capable_of relation] capable_of (inferred) nucleic acid binding transcription factor activity (GO:0001071)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) regulation of transcription, DNA-templated (GO:0006355)
core mediator complex [Inferred related_to relation] related_to (inferred) RNA polymerase activity (GO:0034062)
core mediator complex [Inferred part_of relation] part_of (inferred) transferase complex, transferring phosphorus-containing groups (GO:0061695)
core mediator complex [Inferred related_to relation] related_to (inferred) DNA-directed RNA polymerase activity (GO:0003899)
core mediator complex [Inferred part_of relation] part_of (inferred) nuclear lumen (GO:0031981)
core mediator complex [Inferred part_of relation] part_of (inferred) RNA polymerase complex (GO:0030880)
core mediator complex [Inferred capable_of part of relation] capable_of part of (inferred) transcription factor activity, sequence-specific DNA binding (GO:0003700)
core mediator complex [Inferred part_of relation] part_of (inferred) DNA-directed RNA polymerase complex (GO:0000428)
core mediator complex [Inferred part_of relation] part_of (inferred) nucleoplasm (GO:0005654)
core mediator complex [Inferred is_a relation] is_a (inferred) transcription factor complex (GO:0005667)
core mediator complex [Inferred part_of relation] part_of (inferred) nuclear DNA-directed RNA polymerase complex (GO:0055029)
core mediator complex [Inferred is_a relation] is_a (inferred) nuclear transcription factor complex (GO:0044798)
core mediator complex [Inferred part_of relation] part_of (inferred) nucleoplasm part (GO:0044451)
core mediator complex [Inferred capable_of relation] capable_of (inferred) transcription from RNA polymerase II promoter (GO:0006366)
core mediator complex [part_of relation] part_of  DNA-directed RNA polymerase II, holoenzyme (GO:0016591)
core mediator complex [is_a relation] is_a  RNA polymerase II transcription factor complex (GO:0090575)

This term has no children.

None.