Term Information [More information on gamma-secretase complex]

Accession
GO:0070765
Name
gamma-secretase complex
Ontology
cellular_component
Synonyms
gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN), CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant), gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant), gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN), gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
Definition
A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein. Source: PMID:15890777, GOC:mah, PMID:15286082, PMID:17047368
Comment
None
History
See term history for GO:0070765 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0070765 from QuickGO

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Ancestors of gamma-secretase complex (GO:0070765)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
gamma-secretase complex [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
gamma-secretase complex [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
gamma-secretase complex [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
gamma-secretase complex [Inferred part_of relation] part_of (inferred) cell periphery (GO:0071944)
gamma-secretase complex [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
gamma-secretase complex [Inferred part_of relation] part_of (inferred) membrane (GO:0016020)
gamma-secretase complex [Inferred is_a relation] is_a (inferred) membrane part (GO:0044425)
gamma-secretase complex [Inferred part_of relation] part_of (inferred) plasma membrane (GO:0005886)
gamma-secretase complex [is_a relation] is_a  protein complex (GO:0043234)
gamma-secretase complex [Inferred is_a relation] is_a (inferred) membrane protein complex (GO:0098796)
gamma-secretase complex [is_a relation] is_a  plasma membrane part (GO:0044459)
gamma-secretase complex [is_a relation] is_a  plasma membrane protein complex (GO:0098797)

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None.