Term Information [More information on RISC-loading complex]

Accession
GO:0070578
Name
RISC-loading complex
Ontology
cellular_component
Synonyms
miRLC, microRNA loading complex, RLC
Definition
A trimeric ribonucleoprotein complex that and is required for the formation of a mature RNA induced silencing complex (RISC). In humans the complex is composed of the endonuclease Dicer (DICER1) and TRBP (TARBP2) in association with the Argonaute protein Ago2 (EIF2C2/AGO2). Within the complex, Dicer and TRBP are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto Ago2. Ago2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from Dicer and TRBP. This complex has endoribonuclease activity. Source: GOC:rph, GOC:ab, PMID:19820710, GOC:BHF, PMID:18178619, GOC:nc
Comment
None
History
See term history for GO:0070578 at QuickGO
Subset
None
Community
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Graph of GO:0070578 from QuickGO

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Ancestors of RISC-loading complex (GO:0070578)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) biological_process (GO:0008150)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular process (GO:0009987)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) metabolic process (GO:0008152)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular metabolic process (GO:0044237)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) nitrogen compound metabolic process (GO:0006807)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) organic substance metabolic process (GO:0071704)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular aromatic compound metabolic process (GO:0006725)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular nitrogen compound metabolic process (GO:0034641)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) heterocycle metabolic process (GO:0046483)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) molecular_function (GO:0003674)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) organic cyclic compound metabolic process (GO:1901360)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) primary metabolic process (GO:0044238)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) catalytic activity (GO:0003824)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) macromolecule metabolic process (GO:0043170)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) nucleobase-containing compound metabolic process (GO:0006139)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) cellular macromolecule metabolic process (GO:0044260)
RISC-loading complex [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
RISC-loading complex [Inferred capable_of relation] capable_of (inferred) hydrolase activity (GO:0016787)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) nucleic acid metabolic process (GO:0090304)
RISC-loading complex [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) hydrolase activity, acting on ester bonds (GO:0016788)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) nucleic acid phosphodiester bond hydrolysis (GO:0090305)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) RNA metabolic process (GO:0016070)
RISC-loading complex [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
RISC-loading complex [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
RISC-loading complex [Inferred capable_of relation] capable_of (inferred) nuclease activity (GO:0004518)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) RNA phosphodiester bond hydrolysis (GO:0090501)
RISC-loading complex [Inferred capable_of relation] capable_of (inferred) endonuclease activity (GO:0004519)
RISC-loading complex [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
RISC-loading complex [Inferred is_a relation] is_a (inferred) protein complex (GO:0043234)
RISC-loading complex [Inferred capable_of relation] capable_of (inferred) ribonuclease activity (GO:0004540)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)
RISC-loading complex [Inferred is_a relation] is_a (inferred) catalytic complex (GO:1902494)
RISC-loading complex [Inferred capable_of part of relation] capable_of part of (inferred) endoribonuclease activity (GO:0004521)
RISC-loading complex [Inferred is_a relation] is_a (inferred) intracellular part (GO:0044424)
RISC-loading complex [Inferred is_a relation] is_a (inferred) ribonucleoprotein complex (GO:1990904)
RISC-loading complex [is_a relation] is_a  endoribonuclease complex (GO:1902555)
RISC-loading complex [is_a relation] is_a  intracellular ribonucleoprotein complex (GO:0030529)

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