Term Information [More information on ERK1 and ERK2 cascade]

Accession
GO:0070371
Name
ERK1 and ERK2 cascade
Ontology
biological_process
Synonyms
ERK1 and ERK2 signaling pathway, ERK1 and ERK2 signalling pathway, ERK1/2 cascade, extracellular signal-regulated kinase 1/2 (ERK1/2) cascade, extracellular signal-regulated kinase 1/2 cascade, ERK1 cascade, ERK2 cascade, MAPK1 cascade, MAPK3 cascade, ERK cascade
Definition
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. Source: ISBN:0896039986, PMID:20811974, GOC:signaling, GOC:add, ISBN:0121245462
Comment
Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases.
History
See term history for GO:0070371 at QuickGO
Subset
None
Community
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Feedback
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Ancestors of ERK1 and ERK2 cascade (GO:0070371)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ERK1 and ERK2 cascade [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) metabolic process (GO:0008152)
ERK1 and ERK2 cascade [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) organic substance metabolic process (GO:0071704)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) cellular metabolic process (GO:0044237)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) macromolecule metabolic process (GO:0043170)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) primary metabolic process (GO:0044238)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) cellular macromolecule metabolic process (GO:0044260)
ERK1 and ERK2 cascade [Inferred occurs_in relation] occurs_in (inferred) cellular_component (GO:0005575)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) macromolecule modification (GO:0043412)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) phosphorus metabolic process (GO:0006793)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) protein metabolic process (GO:0019538)
ERK1 and ERK2 cascade [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
ERK1 and ERK2 cascade [Inferred occurs_in relation] occurs_in (inferred) cell (GO:0005623)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) cellular protein metabolic process (GO:0044267)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) phosphate-containing compound metabolic process (GO:0006796)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) protein modification process (GO:0036211)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
ERK1 and ERK2 cascade [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
ERK1 and ERK2 cascade [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
ERK1 and ERK2 cascade [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
ERK1 and ERK2 cascade [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
ERK1 and ERK2 cascade [Inferred occurs_in relation] occurs_in (inferred) cell part (GO:0044464)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) cellular protein modification process (GO:0006464)
ERK1 and ERK2 cascade [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) phosphorylation (GO:0016310)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
ERK1 and ERK2 cascade [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
ERK1 and ERK2 cascade [Inferred occurs_in relation] occurs_in (inferred) intracellular (GO:0005622)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) protein phosphorylation (GO:0006468)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) single-organism metabolic process (GO:0044710)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) intracellular signal transduction (GO:0035556)
ERK1 and ERK2 cascade [Inferred is_a relation] is_a (inferred) signal transduction by protein phosphorylation (GO:0023014)
ERK1 and ERK2 cascade [is_a relation] is_a  MAPK cascade (GO:0000165)
Children of ERK1 and ERK2 cascade (GO:0070371)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of ERK1 and ERK2 cascade (GO:0070373) [negatively_regulates relation] negatively_regulates  ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade (GO:0070374) [positively_regulates relation] positively_regulates  ERK1 and ERK2 cascade
regulation of ERK1 and ERK2 cascade (GO:0070372) [regulates relation] regulates  ERK1 and ERK2 cascade