Term Information [More information on cornification]

Accession
GO:0070268
Name
cornification
Ontology
biological_process
Synonyms
None
Definition
A type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability). Source: GOC:krc, PMID:18846107
Comment
None
History
See term history for GO:0070268 at QuickGO
Subset
None
Community
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Graph of GO:0070268 from QuickGO

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Ancestors of cornification (GO:0070268)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cornification [Inferred occurs_in relation] occurs_in (inferred) anatomical entity (UBERON:0001062)
cornification [Inferred occurs_in relation] occurs_in (inferred) material anatomical entity (UBERON:0000465)
cornification [Inferred occurs_in relation] occurs_in (inferred) material anatomical entity (CARO:0000006)
cornification [Inferred occurs_in relation] occurs_in (inferred) anatomical structure (UBERON:0000061)
cornification [Inferred occurs_in relation] occurs_in (inferred) anatomical structure (CARO:0000003)
cornification [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
cornification [Inferred occurs_in relation] occurs_in (inferred) cell (CL:0000000)
cornification [Inferred occurs_in relation] occurs_in (inferred) multicellular anatomical structure (UBERON:0010000)
cornification [Inferred part_of relation] part_of (inferred) cellular process (GO:0009987)
cornification [Inferred part_of relation] part_of (inferred) developmental process (GO:0032502)
cornification [Inferred occurs_in relation] occurs_in (inferred) multicellular organism (UBERON:0000468)
cornification [Inferred part_of relation] part_of (inferred) multicellular organismal process (GO:0032501)
cornification [Inferred occurs_in relation] occurs_in (inferred) native cell (CL:0000003)
cornification [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
cornification [Inferred part_of relation] part_of (inferred) anatomical structure development (GO:0048856)
cornification [Inferred occurs_in relation] occurs_in (inferred) eukaryotic cell (CL:0000255)
cornification [Inferred part_of relation] part_of (inferred) single-multicellular organism process (GO:0044707)
cornification [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
cornification [Inferred part_of relation] part_of (inferred) single-organism developmental process (GO:0044767)
cornification [Inferred occurs_in relation] occurs_in (inferred) tissue (UBERON:0000479)
cornification [Inferred occurs_in relation] occurs_in (inferred) anatomical system (UBERON:0000467)
cornification [Inferred occurs_in relation] occurs_in (inferred) animal cell (CL:0000548)
cornification [Inferred part_of relation] part_of (inferred) cellular developmental process (GO:0048869)
cornification [Inferred occurs_in relation] occurs_in (inferred) epithelium (UBERON:0000483)
cornification [Inferred part_of relation] part_of (inferred) multicellular organism development (GO:0007275)
cornification [Inferred part_of relation] part_of (inferred) tissue development (GO:0009888)
cornification [Inferred part_of relation] part_of (inferred) cell differentiation (GO:0030154)
cornification [Inferred occurs_in relation] occurs_in (inferred) ectoderm-derived structure (UBERON:0004121)
cornification [Inferred occurs_in relation] occurs_in (inferred) epithelial cell (CL:0000066)
cornification [Inferred part_of relation] part_of (inferred) epithelium development (GO:0060429)
cornification [Inferred occurs_in relation] occurs_in (inferred) integumental system (UBERON:0002416)
cornification [Inferred occurs_in relation] occurs_in (inferred) somatic cell (CL:0002371)
cornification [Inferred part_of relation] part_of (inferred) system development (GO:0048731)
cornification [Inferred part_of relation] part_of (inferred) animal organ development (GO:0048513)
cornification [Inferred occurs_in relation] occurs_in (inferred) ecto-epithelial cell (CL:0002077)
cornification [Inferred occurs_in relation] occurs_in (inferred) ecto-epithelium (UBERON:0010371)
cornification [Inferred part_of relation] part_of (inferred) epidermis development (GO:0008544)
cornification [Inferred part_of relation] part_of (inferred) epithelial cell differentiation (GO:0030855)
cornification [Inferred occurs_in relation] occurs_in (inferred) surface structure (UBERON:0003102)
cornification [Inferred part_of relation] part_of (inferred) epidermal cell differentiation (GO:0009913)
cornification [Inferred occurs_in relation] occurs_in (inferred) general ecto-epithelial cell (CL:0002159)
cornification [Inferred occurs_in relation] occurs_in (inferred) outer epithelium (UBERON:0007376)
cornification [Inferred part_of relation] part_of (inferred) skin development (GO:0043588)
cornification [Inferred is_a relation] is_a (inferred) cell death (GO:0008219)
cornification [Inferred occurs_in relation] occurs_in (inferred) epidermal cell (CL:0000362)
cornification [Inferred part_of relation] part_of (inferred) keratinocyte differentiation (GO:0030216)
cornification [part_of relation] part_of  keratinization (GO:0031424)
cornification [is_a relation] is_a  programmed cell death (GO:0012501)

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