Term Information [More information on necrotic cell death]

Accession
GO:0070265
Name
necrotic cell death
Ontology
biological_process
Synonyms
cellular necrosis, necrosis
Definition
A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. Source: PMID:20823910, GOC:mtg_apoptosis, PMID:18846107
Comment
Note that the word necrosis has been widely used in earlier literature to describe forms of cell death which are now known by more precise terms, such as apoptosis. Necrosis can occur in a regulated fashion, involving a precise sequence of signals; in this case, consider annotating to GO:0097300 'programmed necrotic cell death' or to its more specific child GO:0070266 'necroptotic process'.
History
See term history for GO:0070265 at QuickGO
Subset
None
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
Contact the GO Helpdesk if you find mistakes or have concerns about the data you find here.
Contacting server...
View this term in QuickGO.

Graph of GO:0070265 from QuickGO

Additional external viewing options
Additional internal viewing options
Ancestors of necrotic cell death (GO:0070265)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
necrotic cell death [Inferred is_a relation] is_a (inferred) biological_process (GO:0008150)
necrotic cell death [Inferred is_a relation] is_a (inferred) cellular process (GO:0009987)
necrotic cell death [Inferred is_a relation] is_a (inferred) single-organism process (GO:0044699)
necrotic cell death [Inferred is_a relation] is_a (inferred) single-organism cellular process (GO:0044763)
necrotic cell death [is_a relation] is_a  cell death (GO:0008219)
Children of necrotic cell death (GO:0070265)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of necrotic cell death (GO:0060547) [negatively_regulates relation] negatively_regulates  necrotic cell death
oncosis (GO:0070267) [part_of relation] part_of  necrotic cell death
positive regulation of necrotic cell death (GO:0010940) [positively_regulates relation] positively_regulates  necrotic cell death
programmed necrotic cell death (GO:0097300) [is_a relation] is_a  necrotic cell death
regulation of necrotic cell death (GO:0010939) [regulates relation] regulates  necrotic cell death
None.