Term Information [More information on canonical Wnt signaling pathway]

Accession
GO:0060070
Name
canonical Wnt signaling pathway
Ontology
biological_process
Synonyms
Wnt receptor signaling pathway through beta-catenin, Wnt receptor signaling pathway via beta-catenin, Wnt receptor signalling pathway through beta-catenin, canonical Wnt receptor signaling pathway, canonical Wnt-activated signaling pathway, frizzled-1 receptor signaling pathway
Definition
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. Source: GOC:dph, PMID:19619488, PMID:11532397, GOC:bf
Comment
None
History
See term history for GO:0060070 at QuickGO
Subset
None
Community
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Feedback
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Contacting server...
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Graph of GO:0060070 from QuickGO

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Ancestors of canonical Wnt signaling pathway (GO:0060070)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
canonical Wnt signaling pathway [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
canonical Wnt signaling pathway [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
canonical Wnt signaling pathway [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
canonical Wnt signaling pathway [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
canonical Wnt signaling pathway [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
canonical Wnt signaling pathway [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
canonical Wnt signaling pathway [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
canonical Wnt signaling pathway [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
canonical Wnt signaling pathway [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
canonical Wnt signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
canonical Wnt signaling pathway [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
canonical Wnt signaling pathway [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
canonical Wnt signaling pathway [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
canonical Wnt signaling pathway [Inferred is_a relation] is_a (inferred) cell surface receptor signaling pathway (GO:0007166)
canonical Wnt signaling pathway [is_a relation] is_a  Wnt signaling pathway (GO:0016055)
Children of canonical Wnt signaling pathway (GO:0060070)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
beta-catenin destruction complex disassembly (GO:1904886) [part_of relation] part_of  canonical Wnt signaling pathway
beta-catenin-TCF complex (GO:1990907) [capable_of part of relation] capable_of part of  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment (GO:0061317) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development (GO:0061310) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in heart development (GO:0061316) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation (GO:0044338) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in mesonephric nephron development (GO:0061293) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in mesonephros development (GO:0061292) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in metanephric kidney development (GO:0061290) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation (GO:1904954) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in negative regulation of apoptotic process (GO:0044336) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in neural crest cell differentiation (GO:0044335) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation (GO:0060823) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in osteoblast differentiation (GO:0044339) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in positive regulation of apoptotic process (GO:0044337) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion (GO:0044329) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration (GO:0044328) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition (GO:0044334) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in positive regulation of wound healing (GO:0044330) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in regulation of cell proliferation (GO:0044340) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation (GO:0044343) [is_a relation] is_a  canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in ureteric bud branching (GO:0061291) [is_a relation] is_a  canonical Wnt signaling pathway
coreceptor activity involved in canonical Wnt signaling pathway (GO:1904928) [part_of relation] part_of  canonical Wnt signaling pathway
negative regulation of canonical Wnt signaling pathway (GO:0090090) [negatively_regulates relation] negatively_regulates  canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway (GO:0090263) [positively_regulates relation] positively_regulates  canonical Wnt signaling pathway
positive regulation of spinal cord association neuron differentiation by canonical Wnt signaling pathway (GO:0100067) [is_a relation] is_a  canonical Wnt signaling pathway
receptor internalization involved in canonical Wnt signaling pathway (GO:2000286) [part_of relation] part_of  canonical Wnt signaling pathway
regulation of canonical Wnt signaling pathway (GO:0060828) [regulates relation] regulates  canonical Wnt signaling pathway
regulation of hair cycle by canonical Wnt signaling pathway (GO:0060901) [is_a relation] is_a  canonical Wnt signaling pathway
regulation of heart induction by canonical Wnt signaling pathway (GO:0100012) [is_a relation] is_a  canonical Wnt signaling pathway
Wnt signalosome (GO:1990909) [capable_of part of relation] capable_of part of  canonical Wnt signaling pathway
None.