Term Information [More information on isotype switching]

Accession
GO:0045190
Name
isotype switching
Ontology
biological_process
Synonyms
class switch recombination, class switching, isotype switch recombination
Definition
The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. Source: ISBN:0781735149
Comment
Note that IgM and IgD can be coexpressed by B cells via an alternate splicing mechanism, but true recombinational isotype switching to IgD has been demonstrated as well. Note that this term is best used to annotate gene products which are involved in the mechanism of DNA recombination used in isotype switching, like the B cell specific Swap70 factor in the mouse, rather than gene products which promote isotype switching such as cytokines or co-stimulatory molecules, which should instead be annotated to 'regulation of isotype switching ; GO:0045191'.
History
See term history for GO:0045190 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0045190 from QuickGO

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Ancestors of isotype switching (GO:0045190)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
isotype switching [Inferred part_of relation] part_of (inferred) biological_process (GO:0008150)
isotype switching [Inferred is_a relation] is_a (inferred) cellular process (GO:0009987)
isotype switching [Inferred is_a relation] is_a (inferred) metabolic process (GO:0008152)
isotype switching [Inferred is_a relation] is_a (inferred) cellular metabolic process (GO:0044237)
isotype switching [Inferred is_a relation] is_a (inferred) nitrogen compound metabolic process (GO:0006807)
isotype switching [Inferred is_a relation] is_a (inferred) organic substance metabolic process (GO:0071704)
isotype switching [Inferred is_a relation] is_a (inferred) cellular aromatic compound metabolic process (GO:0006725)
isotype switching [Inferred is_a relation] is_a (inferred) cellular nitrogen compound metabolic process (GO:0034641)
isotype switching [Inferred part_of relation] part_of (inferred) developmental process (GO:0032502)
isotype switching [Inferred is_a relation] is_a (inferred) heterocycle metabolic process (GO:0046483)
isotype switching [Inferred part_of relation] part_of (inferred) immune system process (GO:0002376)
isotype switching [Inferred part_of relation] part_of (inferred) multicellular organismal process (GO:0032501)
isotype switching [Inferred is_a relation] is_a (inferred) organic cyclic compound metabolic process (GO:1901360)
isotype switching [Inferred is_a relation] is_a (inferred) primary metabolic process (GO:0044238)
isotype switching [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
isotype switching [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
isotype switching [Inferred part_of relation] part_of (inferred) anatomical structure development (GO:0048856)
isotype switching [Inferred part_of relation] part_of (inferred) immune effector process (GO:0002252)
isotype switching [Inferred part_of relation] part_of (inferred) immune response (GO:0006955)
isotype switching [Inferred is_a relation] is_a (inferred) macromolecule metabolic process (GO:0043170)
isotype switching [Inferred is_a relation] is_a (inferred) nucleobase-containing compound metabolic process (GO:0006139)
isotype switching [Inferred part_of relation] part_of (inferred) single-multicellular organism process (GO:0044707)
isotype switching [Inferred part_of relation] part_of (inferred) single-organism developmental process (GO:0044767)
isotype switching [Inferred part_of relation] part_of (inferred) adaptive immune response (GO:0002250)
isotype switching [Inferred is_a relation] is_a (inferred) cellular macromolecule metabolic process (GO:0044260)
isotype switching [Inferred part_of relation] part_of (inferred) leukocyte mediated immunity (GO:0002443)
isotype switching [Inferred part_of relation] part_of (inferred) multicellular organism development (GO:0007275)
isotype switching [Inferred is_a relation] is_a (inferred) nucleic acid metabolic process (GO:0090304)
isotype switching [Inferred part_of relation] part_of (inferred) adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460)
isotype switching [Inferred is_a relation] is_a (inferred) DNA metabolic process (GO:0006259)
isotype switching [Inferred part_of relation] part_of (inferred) lymphocyte mediated immunity (GO:0002449)
isotype switching [Inferred is_a relation] is_a (inferred) single-organism cellular process (GO:0044763)
isotype switching [Inferred part_of relation] part_of (inferred) system development (GO:0048731)
isotype switching [Inferred part_of relation] part_of (inferred) B cell mediated immunity (GO:0019724)
isotype switching [Inferred is_a relation] is_a (inferred) cell activation (GO:0001775)
isotype switching [Inferred is_a relation] is_a (inferred) DNA recombination (GO:0006310)
isotype switching [Inferred part_of relation] part_of (inferred) immune system development (GO:0002520)
isotype switching [Inferred part_of relation] part_of (inferred) production of molecular mediator of immune response (GO:0002440)
isotype switching [Inferred is_a relation] is_a (inferred) cell activation involved in immune response (GO:0002263)
isotype switching [Inferred part_of relation] part_of (inferred) immunoglobulin mediated immune response (GO:0016064)
isotype switching [Inferred part_of relation] part_of (inferred) immunoglobulin production (GO:0002377)
isotype switching [Inferred is_a relation] is_a (inferred) leukocyte activation (GO:0045321)
isotype switching [Inferred is_a relation] is_a (inferred) somatic cell DNA recombination (GO:0016444)
isotype switching [Inferred is_a relation] is_a (inferred) somatic diversification of immune receptors (GO:0002200)
isotype switching [Inferred part_of relation] part_of (inferred) immunoglobulin production involved in immunoglobulin mediated immune response (GO:0002381)
isotype switching [Inferred is_a relation] is_a (inferred) leukocyte activation involved in immune response (GO:0002366)
isotype switching [Inferred is_a relation] is_a (inferred) lymphocyte activation (GO:0046649)
isotype switching [Inferred is_a relation] is_a (inferred) somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562)
isotype switching [Inferred is_a relation] is_a (inferred) somatic diversification of immunoglobulins (GO:0016445)
isotype switching [Inferred is_a relation] is_a (inferred) B cell activation (GO:0042113)
isotype switching [Inferred is_a relation] is_a (inferred) lymphocyte activation involved in immune response (GO:0002285)
isotype switching [Inferred is_a relation] is_a (inferred) somatic diversification of immunoglobulins involved in immune response (GO:0002208)
isotype switching [Inferred is_a relation] is_a (inferred) somatic recombination of immunoglobulin gene segments (GO:0016447)
isotype switching [is_a relation] is_a  B cell activation involved in immune response (GO:0002312)
isotype switching [is_a relation] is_a  single-organism metabolic process (GO:0044710)
isotype switching [is_a relation] is_a  somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)
Children of isotype switching (GO:0045190)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
isotype switching to IgA isotypes (GO:0048290) [is_a relation] is_a  isotype switching
isotype switching to IgD isotypes (GO:0048292) [is_a relation] is_a  isotype switching
isotype switching to IgE isotypes (GO:0048289) [is_a relation] is_a  isotype switching
isotype switching to IgG isotypes (GO:0048291) [is_a relation] is_a  isotype switching
negative regulation of isotype switching (GO:0045829) [negatively_regulates relation] negatively_regulates  isotype switching
positive regulation of isotype switching (GO:0045830) [positively_regulates relation] positively_regulates  isotype switching
regulation of isotype switching (GO:0045191) [regulates relation] regulates  isotype switching