Term Information [More information on natural killer cell mediated cytotoxicity]

Accession
GO:0042267
Name
natural killer cell mediated cytotoxicity
Ontology
biological_process
Synonyms
NK cell mediated cell death, NK cell mediated cell killing, NK cell mediated cytotoxicity, natural killer cell mediated cell death, natural killer cell mediated cell killing, NK cell mediated cytolysis, killer activity, natural killer cell mediated cytolysis, natural killer-cell mediated cytolysis
Definition
The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. Source: GOC:add, GOC:pr
Comment
Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
History
See term history for GO:0042267 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0042267 from QuickGO

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Ancestors of natural killer cell mediated cytotoxicity (GO:0042267)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
natural killer cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) biological_process (GO:0008150)
natural killer cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) immune system process (GO:0002376)
natural killer cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) response to stimulus (GO:0050896)
natural killer cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) immune effector process (GO:0002252)
natural killer cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) response to stress (GO:0006950)
natural killer cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) defense response (GO:0006952)
natural killer cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) immune response (GO:0006955)
natural killer cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) leukocyte mediated immunity (GO:0002443)
natural killer cell mediated cytotoxicity [is_a relation] is_a  cell killing (GO:0001906)
natural killer cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) innate immune response (GO:0045087)
natural killer cell mediated cytotoxicity [Inferred is_a relation] is_a (inferred) lymphocyte mediated immunity (GO:0002449)
natural killer cell mediated cytotoxicity [is_a relation] is_a  leukocyte mediated cytotoxicity (GO:0001909)
natural killer cell mediated cytotoxicity [is_a relation] is_a  natural killer cell mediated immunity (GO:0002228)
natural killer cell mediated cytotoxicity [is_a relation] is_a  single-organism process (GO:0044699)
Children of natural killer cell mediated cytotoxicity (GO:0042267)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
natural killer cell degranulation (GO:0043320) [part_of relation] part_of  natural killer cell mediated cytotoxicity
natural killer cell mediated cytotoxicity directed against tumor cell target (GO:0002420) [is_a relation] is_a  natural killer cell mediated cytotoxicity
negative regulation of natural killer cell mediated cytotoxicity (GO:0045953) [negatively_regulates relation] negatively_regulates  natural killer cell mediated cytotoxicity
positive regulation of natural killer cell mediated cytotoxicity (GO:0045954) [positively_regulates relation] positively_regulates  natural killer cell mediated cytotoxicity
regulation of natural killer cell mediated cytotoxicity (GO:0042269) [regulates relation] regulates  natural killer cell mediated cytotoxicity
None.