Term Information [More information on RIG-I signaling pathway]

Accession
GO:0039529
Name
RIG-I signaling pathway
Ontology
biological_process
Synonyms
DDX58 signaling pathway, RIG-I signalling pathway, retinoic acid inducible gene I signaling pathway
Definition
Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. Source: PMID:21435580, GOC:bf, PMID:19620789, PMID:17328678
Comment
The apoptosis effect triggered by the RIG-I signaling pathway is inconclusive and may represent an in-vitro phenomenon. Therefore, in GO the term 'RIG-I signaling pathway ; GO:0039529' is positioned under 'regulation of cytokine production' as this is its primary effect.
History
See term history for GO:0039529 at QuickGO
Subset
virus_checked
Community
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Feedback
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Graph of GO:0039529 from QuickGO

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Ancestors of RIG-I signaling pathway (GO:0039529)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
RIG-I signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) biological_process (GO:0008150)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
RIG-I signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) response to stimulus (GO:0050896)
RIG-I signaling pathway [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
RIG-I signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) immune system process (GO:0002376)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) regulation of response to stimulus (GO:0048583)
RIG-I signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) response to stress (GO:0006950)
RIG-I signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) single-organism process (GO:0044699)
RIG-I signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) defense response (GO:0006952)
RIG-I signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) immune response (GO:0006955)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of biological process (GO:0048518)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) regulation of immune system process (GO:0002682)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) regulation of response to stress (GO:0080134)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
RIG-I signaling pathway [Inferred occurs_in relation] occurs_in (inferred) cellular_component (GO:0005575)
RIG-I signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) innate immune response (GO:0045087)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of immune system process (GO:0002684)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of response to stimulus (GO:0048584)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) regulation of defense response (GO:0031347)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) regulation of immune response (GO:0050776)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
RIG-I signaling pathway [Inferred occurs_in relation] occurs_in (inferred) cell (GO:0005623)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of defense response (GO:0031349)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of immune response (GO:0050778)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) regulation of innate immune response (GO:0045088)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) activation of immune response (GO:0002253)
RIG-I signaling pathway [Inferred occurs_in relation] occurs_in (inferred) cell part (GO:0044464)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) immune response-regulating signaling pathway (GO:0002764)
RIG-I signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) multicellular organismal process (GO:0032501)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of innate immune response (GO:0045089)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) response to biotic stimulus (GO:0009607)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) response to external stimulus (GO:0009605)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) activation of innate immune response (GO:0002218)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) immune response-activating signal transduction (GO:0002757)
RIG-I signaling pathway [Inferred occurs_in relation] occurs_in (inferred) intracellular (GO:0005622)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) multi-organism process (GO:0051704)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) response to external biotic stimulus (GO:0043207)
RIG-I signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) single-multicellular organism process (GO:0044707)
RIG-I signaling pathway [Inferred positively_regulates relation] positively_regulates (inferred) cytokine production (GO:0001816)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) innate immune response-activating signal transduction (GO:0002758)
RIG-I signaling pathway [Inferred occurs_in relation] occurs_in (inferred) intracellular part (GO:0044424)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) regulation of multicellular organismal process (GO:0051239)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) response to other organism (GO:0051707)
RIG-I signaling pathway [Inferred occurs_in relation] occurs_in (inferred) cytoplasm (GO:0005737)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) defense response to other organism (GO:0098542)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) immune effector process (GO:0002252)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) intracellular receptor signaling pathway (GO:0030522)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) intracellular signal transduction (GO:0035556)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) pattern recognition receptor signaling pathway (GO:0002221)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of multicellular organismal process (GO:0051240)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) regulation of cytokine production (GO:0001817)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) response to virus (GO:0009615)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) cellular response to virus (GO:0098586)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)
RIG-I signaling pathway [Inferred part_of relation] part_of (inferred) defense response to virus (GO:0051607)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) multi-organism cellular process (GO:0044764)
RIG-I signaling pathway [Inferred is_a relation] is_a (inferred) positive regulation of cytokine production (GO:0001819)
RIG-I signaling pathway [is_a relation] is_a  cytoplasmic pattern recognition receptor signaling pathway in response to virus (GO:0039528)
Children of RIG-I signaling pathway (GO:0039529)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of RIG-I signaling pathway (GO:0039536) [negatively_regulates relation] negatively_regulates  RIG-I signaling pathway
positive regulation of RIG-I signaling pathway (GO:1900246) [positively_regulates relation] positively_regulates  RIG-I signaling pathway
regulation of RIG-I signaling pathway (GO:0039535) [regulates relation] regulates  RIG-I signaling pathway
suppression by virus of host RIG-I signaling pathway (GO:0039538) [negatively_regulates relation] negatively_regulates  RIG-I signaling pathway
None.