Term Information [More information on NIK/NF-kappaB signaling]

Accession
GO:0038061
Name
NIK/NF-kappaB signaling
Ontology
biological_process
Synonyms
NIK/NF-kappaB signal transduction, NIK/NF-kappaB cascade, p52-dependent NF-kappaB signaling, non-canonical NF-KB signaling, noncanonical NF-kappaB signaling, noncanonical nuclear factor kappaB (NF-kappaB) pathway
Definition
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). Source: PMID:15140882, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, GOC:bf
Comment
None
History
See term history for GO:0038061 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0038061 from QuickGO

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Ancestors of NIK/NF-kappaB signaling (GO:0038061)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
NIK/NF-kappaB signaling [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
NIK/NF-kappaB signaling [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
NIK/NF-kappaB signaling [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
NIK/NF-kappaB signaling [Inferred occurs_in relation] occurs_in (inferred) cellular_component (GO:0005575)
NIK/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
NIK/NF-kappaB signaling [Inferred occurs_in relation] occurs_in (inferred) cell (GO:0005623)
NIK/NF-kappaB signaling [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
NIK/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
NIK/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
NIK/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
NIK/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
NIK/NF-kappaB signaling [Inferred occurs_in relation] occurs_in (inferred) cell part (GO:0044464)
NIK/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
NIK/NF-kappaB signaling [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
NIK/NF-kappaB signaling [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
NIK/NF-kappaB signaling [Inferred occurs_in relation] occurs_in (inferred) intracellular (GO:0005622)
NIK/NF-kappaB signaling [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
NIK/NF-kappaB signaling [is_a relation] is_a  intracellular signal transduction (GO:0035556)
Children of NIK/NF-kappaB signaling (GO:0038061)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
activation of NF-kappaB-inducing kinase activity (GO:0007250) [part_of relation] part_of  NIK/NF-kappaB signaling
negative regulation of NIK/NF-kappaB signaling (GO:1901223) [negatively_regulates relation] negatively_regulates  NIK/NF-kappaB signaling
NF-kappaB-inducing kinase activity (GO:0004704) [part_of relation] part_of  NIK/NF-kappaB signaling
positive regulation of NIK/NF-kappaB signaling (GO:1901224) [positively_regulates relation] positively_regulates  NIK/NF-kappaB signaling
regulation of NIK/NF-kappaB signaling (GO:1901222) [regulates relation] regulates  NIK/NF-kappaB signaling
None.