Term Information [More information on ERAD pathway]

Accession
GO:0036503
Name
ERAD pathway
Ontology
biological_process
Synonyms
endoplasmic reticulum-associated degradation, protein degradation by ERAD, ER-associated degradation pathway, endoplasmic reticulum-associated protein degradation pathway
Definition
The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. Source: GOC:PARL, GOC:bf
Comment
None
History
See term history for GO:0036503 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0036503 from QuickGO

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Ancestors of ERAD pathway (GO:0036503)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
ERAD pathway [Inferred is_a relation] is_a (inferred) biological_process (GO:0008150)
ERAD pathway [Inferred is_a relation] is_a (inferred) metabolic process (GO:0008152)
ERAD pathway [Inferred is_a relation] is_a (inferred) catabolic process (GO:0009056)
ERAD pathway [Inferred is_a relation] is_a (inferred) cellular process (GO:0009987)
ERAD pathway [Inferred is_a relation] is_a (inferred) organic substance metabolic process (GO:0071704)
ERAD pathway [Inferred is_a relation] is_a (inferred) response to stimulus (GO:0050896)
ERAD pathway [Inferred is_a relation] is_a (inferred) cellular response to stimulus (GO:0051716)
ERAD pathway [Inferred is_a relation] is_a (inferred) macromolecule metabolic process (GO:0043170)
ERAD pathway [Inferred is_a relation] is_a (inferred) organic substance catabolic process (GO:1901575)
ERAD pathway [Inferred is_a relation] is_a (inferred) primary metabolic process (GO:0044238)
ERAD pathway [Inferred is_a relation] is_a (inferred) response to stress (GO:0006950)
ERAD pathway [Inferred is_a relation] is_a (inferred) single-organism process (GO:0044699)
ERAD pathway [Inferred is_a relation] is_a (inferred) cellular response to stress (GO:0033554)
ERAD pathway [Inferred is_a relation] is_a (inferred) macromolecule catabolic process (GO:0009057)
ERAD pathway [Inferred is_a relation] is_a (inferred) protein metabolic process (GO:0019538)
ERAD pathway [Inferred is_a relation] is_a (inferred) response to chemical (GO:0042221)
ERAD pathway [Inferred is_a relation] is_a (inferred) single-organism metabolic process (GO:0044710)
ERAD pathway [is_a relation] is_a  protein catabolic process (GO:0030163)
ERAD pathway [is_a relation] is_a  response to endoplasmic reticulum stress (GO:0034976)
ERAD pathway [is_a relation] is_a  response to organic substance (GO:0010033)
ERAD pathway [is_a relation] is_a  single-organism catabolic process (GO:0044712)
ERAD pathway [is_a relation] is_a  single-organism cellular process (GO:0044763)
Children of ERAD pathway (GO:0036503)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
CUE1-UBC7 ubiquitin-conjugating enzyme complex (GO:1990389) [capable_of part of relation] capable_of part of  ERAD pathway
Doa10p ubiquitin ligase complex (GO:0000837) [capable_of part of relation] capable_of part of  ERAD pathway
ER ubiquitin ligase complex (GO:0000835) [capable_of part of relation] capable_of part of  ERAD pathway
ER-associated ubiquitin-dependent protein catabolic process (GO:0030433) [part_of relation] part_of  ERAD pathway
glycoprotein ERAD pathway (GO:0097466) [is_a relation] is_a  ERAD pathway
Hrd1p ubiquitin ligase complex (GO:0000836) [capable_of part of relation] capable_of part of  ERAD pathway
Hrd1p ubiquitin ligase ERAD-L complex (GO:0000839) [capable_of part of relation] capable_of part of  ERAD pathway
Hrd1p ubiquitin ligase ERAD-M complex (GO:0000838) [capable_of part of relation] capable_of part of  ERAD pathway
maintenance of unfolded protein involved in ERAD pathway (GO:1904378) [part_of relation] part_of  ERAD pathway
negative regulation of ERAD pathway (GO:1904293) [negatively_regulates relation] negatively_regulates  ERAD pathway
positive regulation of ERAD pathway (GO:1904294) [positively_regulates relation] positively_regulates  ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway (GO:1904379) [part_of relation] part_of  ERAD pathway
regulation of ERAD pathway (GO:1904292) [regulates relation] regulates  ERAD pathway
retrograde protein transport, ER to cytosol (GO:0030970) [part_of relation] part_of  ERAD pathway
ubiquitin protein ligase activity involved in ERAD pathway (GO:1904264) [part_of relation] part_of  ERAD pathway
None.