Term Information [More information on IRE1-mediated unfolded protein response]

Accession
GO:0036498
Name
IRE1-mediated unfolded protein response
Ontology
biological_process
Synonyms
IRE1 branch of UPR, UPR signaling by IRE1 stress sensor, endoplasmic reticulum unfolded protein response; IRE1 signaling, ERN1-mediated unfolded protein response, IRE1 signaling in response to endoplasmic reticulum stress, inositol-requiring enzyme 1-mediated unfolded protein response, inositol-requiring transmembrane kinase/endonuclease signal transduction, IRE1alpha unfolded protein response, IRE1p unfolded protein response, IRE1 signal transduction pathway
Definition
A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB. Source: GOC:PARL, PMID:22013210, GOC:bf
Comment
Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants.
History
See term history for GO:0036498 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0036498 from QuickGO

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Ancestors of IRE1-mediated unfolded protein response (GO:0036498)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
IRE1-mediated unfolded protein response [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
IRE1-mediated unfolded protein response [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) response to chemical (GO:0042221)
IRE1-mediated unfolded protein response [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) cellular response to chemical stimulus (GO:0070887)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) response to organic substance (GO:0010033)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) response to stress (GO:0006950)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) cellular response to organic substance (GO:0071310)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) cellular response to stress (GO:0033554)
IRE1-mediated unfolded protein response [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) response to topologically incorrect protein (GO:0035966)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) cellular response to topologically incorrect protein (GO:0035967)
IRE1-mediated unfolded protein response [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) response to unfolded protein (GO:0006986)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
IRE1-mediated unfolded protein response [Inferred part_of relation] part_of (inferred) cellular response to unfolded protein (GO:0034620)
IRE1-mediated unfolded protein response [Inferred is_a relation] is_a (inferred) response to endoplasmic reticulum stress (GO:0034976)
IRE1-mediated unfolded protein response [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
IRE1-mediated unfolded protein response [is_a relation] is_a  endoplasmic reticulum unfolded protein response (GO:0030968)
Children of IRE1-mediated unfolded protein response (GO:0036498)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response (GO:0030969) [part_of relation] part_of  IRE1-mediated unfolded protein response
negative regulation of IRE1-mediated unfolded protein response (GO:1903895) [negatively_regulates relation] negatively_regulates  IRE1-mediated unfolded protein response
positive regulation of IRE1-mediated unfolded protein response (GO:1903896) [positively_regulates relation] positively_regulates  IRE1-mediated unfolded protein response
regulation of IRE1-mediated unfolded protein response (GO:1903894) [regulates relation] regulates  IRE1-mediated unfolded protein response
None.