Term Information [More information on gene silencing by miRNA]

Accession
GO:0035195
Name
gene silencing by miRNA
Ontology
biological_process
Synonyms
gene silencing by microRNA, miRNA-mediated gene silencing, microRNA-mediated gene silencing
Definition
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of mRNA cleavage or translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. Source: PMID:23209154, PMID:15066283, PMID:14744438, PMID:15066275
Comment
None
History
See term history for GO:0035195 at QuickGO
Subset
None
Community
GN Add usage comments for this term on the GONUTS wiki.
Feedback
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Graph of GO:0035195 from QuickGO

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Ancestors of gene silencing by miRNA (GO:0035195)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) biological_process (GO:0008150)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular process (GO:0009987)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) metabolic process (GO:0008152)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) biosynthetic process (GO:0009058)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular metabolic process (GO:0044237)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) nitrogen compound metabolic process (GO:0006807)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) organic substance metabolic process (GO:0071704)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular biosynthetic process (GO:0044249)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular nitrogen compound metabolic process (GO:0034641)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) macromolecule metabolic process (GO:0043170)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of biological process (GO:0048519)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of metabolic process (GO:0019222)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular amide metabolic process (GO:0043603)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular nitrogen compound biosynthetic process (GO:0044271)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) gene expression (GO:0010467)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of metabolic process (GO:0009892)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) organic substance biosynthetic process (GO:1901576)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) organonitrogen compound metabolic process (GO:1901564)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) primary metabolic process (GO:0044238)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of macromolecule metabolic process (GO:0060255)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) amide biosynthetic process (GO:0043604)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular macromolecule metabolic process (GO:0044260)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) macromolecule biosynthetic process (GO:0009059)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of cellular process (GO:0048523)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of macromolecule metabolic process (GO:0010605)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) organonitrogen compound biosynthetic process (GO:1901566)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) peptide metabolic process (GO:0006518)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) protein metabolic process (GO:0019538)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of biosynthetic process (GO:0009889)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of cellular metabolic process (GO:0031323)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of gene expression (GO:0010468)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of primary metabolic process (GO:0080090)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) single-organism process (GO:0044699)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular macromolecule biosynthetic process (GO:0034645)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) cellular protein metabolic process (GO:0044267)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of biosynthetic process (GO:0009890)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of cellular metabolic process (GO:0031324)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of gene expression (GO:0010629)
gene silencing by miRNA [Inferred negatively_regulates relation] negatively_regulates (inferred) peptide biosynthetic process (GO:0043043)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of cellular biosynthetic process (GO:0031326)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of macromolecule biosynthetic process (GO:0010556)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of nitrogen compound metabolic process (GO:0051171)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of protein metabolic process (GO:0051246)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) single-organism cellular process (GO:0044763)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) gene silencing (GO:0016458)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of cellular biosynthetic process (GO:0031327)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of macromolecule biosynthetic process (GO:0010558)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of nitrogen compound metabolic process (GO:0051172)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of protein metabolic process (GO:0051248)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) posttranscriptional regulation of gene expression (GO:0010608)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of cellular amide metabolic process (GO:0034248)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of cellular macromolecule biosynthetic process (GO:2000112)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of cellular protein metabolic process (GO:0032268)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of gene expression, epigenetic (GO:0040029)
gene silencing by miRNA [negatively_regulates relation] negatively_regulates  translation (GO:0006412)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) gene silencing by RNA (GO:0031047)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of cellular amide metabolic process (GO:0034249)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of cellular macromolecule biosynthetic process (GO:2000113)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) negative regulation of cellular protein metabolic process (GO:0032269)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) posttranscriptional gene silencing (GO:0016441)
gene silencing by miRNA [Inferred is_a relation] is_a (inferred) regulation of translation (GO:0006417)
gene silencing by miRNA [is_a relation] is_a  negative regulation of translation (GO:0017148)
gene silencing by miRNA [is_a relation] is_a  posttranscriptional gene silencing by RNA (GO:0035194)
Children of gene silencing by miRNA (GO:0035195)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
deadenylation involved in gene silencing by miRNA (GO:0098806) [part_of relation] part_of  gene silencing by miRNA
miRNA loading onto RISC involved in gene silencing by miRNA (GO:0035280) [part_of relation] part_of  gene silencing by miRNA
miRNA mediated inhibition of translation (GO:0035278) [part_of relation] part_of  gene silencing by miRNA
mRNA cleavage involved in gene silencing by miRNA (GO:0035279) [part_of relation] part_of  gene silencing by miRNA
negative regulation of gene silencing by miRNA (GO:0060965) [negatively_regulates relation] negatively_regulates  gene silencing by miRNA
positive regulation of gene silencing by miRNA (GO:2000637) [positively_regulates relation] positively_regulates  gene silencing by miRNA
pre-miRNA export from nucleus (GO:0035281) [part_of relation] part_of  gene silencing by miRNA
production of miRNAs involved in gene silencing by miRNA (GO:0035196) [part_of relation] part_of  gene silencing by miRNA
regulation of gene silencing by miRNA (GO:0060964) [regulates relation] regulates  gene silencing by miRNA
None.