Term Information [More information on FACT complex]

Accession
GO:0035101
Name
FACT complex
Ontology
cellular_component
Synonyms
Facilitates chromatin transcription complex
Definition
An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer. Source: GOC:krc, PMID:12934006, PMID:12934007, GOC:expert_tf, GOC:expert_ras, GOC:bf, GOC:expert_ks, PMID:16678108
Comment
None
History
See term history for GO:0035101 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0035101 from QuickGO

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Ancestors of FACT complex (GO:0035101)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
FACT complex [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
FACT complex [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
FACT complex [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
FACT complex [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
FACT complex [Inferred part_of relation] part_of (inferred) intracellular part (GO:0044424)
FACT complex [Inferred part_of relation] part_of (inferred) organelle (GO:0043226)
FACT complex [Inferred part_of relation] part_of (inferred) intracellular organelle (GO:0043229)
FACT complex [Inferred part_of relation] part_of (inferred) membrane-bounded organelle (GO:0043227)
FACT complex [Inferred part_of relation] part_of (inferred) intracellular membrane-bounded organelle (GO:0043231)
FACT complex [Inferred part_of relation] part_of (inferred) membrane-enclosed lumen (GO:0031974)
FACT complex [Inferred part_of relation] part_of (inferred) organelle part (GO:0044422)
FACT complex [Inferred part_of relation] part_of (inferred) intracellular organelle part (GO:0044446)
FACT complex [Inferred part_of relation] part_of (inferred) nucleus (GO:0005634)
FACT complex [Inferred part_of relation] part_of (inferred) organelle lumen (GO:0043233)
FACT complex [Inferred part_of relation] part_of (inferred) intracellular organelle lumen (GO:0070013)
FACT complex [Inferred part_of relation] part_of (inferred) nuclear part (GO:0044428)
FACT complex [Inferred part_of relation] part_of (inferred) nuclear lumen (GO:0031981)
FACT complex [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
FACT complex [Inferred part_of relation] part_of (inferred) nucleoplasm (GO:0005654)
FACT complex [Inferred is_a relation] is_a (inferred) nucleoplasm part (GO:0044451)
FACT complex [Inferred is_a relation] is_a (inferred) protein complex (GO:0043234)
FACT complex [is_a relation] is_a  transcription elongation factor complex (GO:0008023)

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