AmiGO 2: Term Details for "methylosome" (GO:0034709)

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Term Information

Accession: GO:0034709
Name: methylosome
Ontology: cellular_component
Synonyms: 20S methylosome, 20S methyltransferase complex
Alternate IDs: None
Definition: A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. Source: PMID:11756452, PMID:11713266
Comment: None
History: See term history for GO:0034709 at QuickGO
Subset: None
Related: Link to all genes and gene products annotated to methylosome.; Link to all direct and indirect annotations to methylosome.; Link to all direct and indirect annotations download (limited to first 10,000) for methylosome.

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GO:0005575 cellular_component
GO:0005623 cell
GO:0003674 molecular_function
GO:0008150 biological_process
GO:0003824 catalytic activity
GO:0044464 cell part
GO:0005622 intracellular
GO:0032991 macromolecular complex
GO:0008152 metabolic process
GO:0016740 transferase activity
GO:1902494 catalytic complex
GO:0044424 intracellular part
GO:0032259 methylation
GO:0016741 transferase activity, transferring one-carbon groups
GO:0005737 cytoplasm
GO:0008168 methyltransferase activity
GO:1990234 transferase complex
GO:0044444 cytoplasmic part
GO:0034708 methyltransferase complex
GO:0034709 methylosome

Parents of methylosome (GO:0034709)

subject	relation	object
methylosome	is_a	cytoplasmic part (GO:0044444)
methylosome	is_a	methyltransferase complex (GO:0034708)

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