Term Information [More information on methylosome]

Accession
GO:0034709
Name
methylosome
Ontology
cellular_component
Synonyms
20S methylosome, 20S methyltransferase complex
Definition
A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. Source: PMID:11756452, PMID:11713266
Comment
None
History
See term history for GO:0034709 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0034709 from QuickGO

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Ancestors of methylosome (GO:0034709)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
methylosome [Inferred part_of relation] part_of (inferred) cellular_component (GO:0005575)
methylosome [Inferred part_of relation] part_of (inferred) cell (GO:0005623)
methylosome [Inferred capable_of part of relation] capable_of part of (inferred) molecular_function (GO:0003674)
methylosome [Inferred capable_of part of relation] capable_of part of (inferred) biological_process (GO:0008150)
methylosome [Inferred capable_of part of relation] capable_of part of (inferred) catalytic activity (GO:0003824)
methylosome [Inferred part_of relation] part_of (inferred) cell part (GO:0044464)
methylosome [Inferred is_a relation] is_a (inferred) macromolecular complex (GO:0032991)
methylosome [Inferred part_of relation] part_of (inferred) intracellular (GO:0005622)
methylosome [Inferred capable_of part of relation] capable_of part of (inferred) metabolic process (GO:0008152)
methylosome [Inferred is_a relation] is_a (inferred) protein complex (GO:0043234)
methylosome [Inferred capable_of relation] capable_of (inferred) transferase activity (GO:0016740)
methylosome [Inferred is_a relation] is_a (inferred) catalytic complex (GO:1902494)
methylosome [Inferred part_of relation] part_of (inferred) intracellular part (GO:0044424)
methylosome [Inferred capable_of part of relation] capable_of part of (inferred) methylation (GO:0032259)
methylosome [Inferred capable_of part of relation] capable_of part of (inferred) transferase activity, transferring one-carbon groups (GO:0016741)
methylosome [Inferred part_of relation] part_of (inferred) cytoplasm (GO:0005737)
methylosome [Inferred capable_of relation] capable_of (inferred) methyltransferase activity (GO:0008168)
methylosome [Inferred is_a relation] is_a (inferred) transferase complex (GO:1990234)
methylosome [is_a relation] is_a  cytoplasmic part (GO:0044444)
methylosome [is_a relation] is_a  methyltransferase complex (GO:0034708)

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