Term Information [More information on deoxyhypusine synthase activity]

Accession
GO:0034038
Name
deoxyhypusine synthase activity
Ontology
molecular_function
Synonyms
eIF-5A-deoxyhypusine synthase activity, eIF5A-precursor-lysine:spermidine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity, spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) activity
Definition
Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+. Source: EC:2.5.1.46, MetaCyc:2.5.1.46-RXN, GOC:pde
Comment
Note that this term is equivalent to the obsolete molecular function term 'deoxyhypusine synthase activity ; GO:0004171' and corresponds closely to the biological process term 'deoxyhypusine biosynthetic process from spermidine, using deoxyhypusine synthase ; GO:0050983'.
History
See term history for GO:0034038 at QuickGO
Subset
None
Community
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Graph of GO:0034038 from QuickGO

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Ancestors of deoxyhypusine synthase activity (GO:0034038)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
deoxyhypusine synthase activity [Inferred is_a relation] is_a (inferred) molecular_function (GO:0003674)
deoxyhypusine synthase activity [Inferred is_a relation] is_a (inferred) catalytic activity (GO:0003824)
deoxyhypusine synthase activity [Inferred is_a relation] is_a (inferred) transferase activity (GO:0016740)
deoxyhypusine synthase activity [is_a relation] is_a  transferase activity, transferring alkyl or aryl (other than methyl) groups (GO:0016765)

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