Term Information [More information on calcineurin-NFAT signaling cascade]

Accession
GO:0033173
Name
calcineurin-NFAT signaling cascade
Ontology
biological_process
Synonyms
calcineurin-NFAT signaling pathway, calcineurin-NFAT signalling pathway
Definition
Any intracellular signal transduction in which the signal is passed on within the by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). Source: PMID:15928679, GOC:mah, GOC:lm, PMID:12975316
Comment
None
History
See term history for GO:0033173 at QuickGO
Subset
None
Community
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Feedback
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Graph of GO:0033173 from QuickGO

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Ancestors of calcineurin-NFAT signaling cascade (GO:0033173)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
calcineurin-NFAT signaling cascade [Inferred regulates relation] regulates (inferred) biological_process (GO:0008150)
calcineurin-NFAT signaling cascade [Inferred is_a relation] is_a (inferred) biological regulation (GO:0065007)
calcineurin-NFAT signaling cascade [Inferred regulates relation] regulates (inferred) cellular process (GO:0009987)
calcineurin-NFAT signaling cascade [Inferred occurs_in relation] occurs_in (inferred) cellular_component (GO:0005575)
calcineurin-NFAT signaling cascade [Inferred part_of relation] part_of (inferred) single-organism process (GO:0044699)
calcineurin-NFAT signaling cascade [Inferred occurs_in relation] occurs_in (inferred) cell (GO:0005623)
calcineurin-NFAT signaling cascade [Inferred is_a relation] is_a (inferred) regulation of biological process (GO:0050789)
calcineurin-NFAT signaling cascade [Inferred part_of relation] part_of (inferred) response to stimulus (GO:0050896)
calcineurin-NFAT signaling cascade [Inferred part_of relation] part_of (inferred) signaling (GO:0023052)
calcineurin-NFAT signaling cascade [Inferred part_of relation] part_of (inferred) single-organism cellular process (GO:0044763)
calcineurin-NFAT signaling cascade [Inferred part_of relation] part_of (inferred) cell communication (GO:0007154)
calcineurin-NFAT signaling cascade [Inferred occurs_in relation] occurs_in (inferred) cell part (GO:0044464)
calcineurin-NFAT signaling cascade [Inferred part_of relation] part_of (inferred) cellular response to stimulus (GO:0051716)
calcineurin-NFAT signaling cascade [Inferred is_a relation] is_a (inferred) regulation of cellular process (GO:0050794)
calcineurin-NFAT signaling cascade [Inferred part_of relation] part_of (inferred) single organism signaling (GO:0044700)
calcineurin-NFAT signaling cascade [Inferred occurs_in relation] occurs_in (inferred) intracellular (GO:0005622)
calcineurin-NFAT signaling cascade [Inferred is_a relation] is_a (inferred) signal transduction (GO:0007165)
calcineurin-NFAT signaling cascade [Inferred is_a relation] is_a (inferred) intracellular signal transduction (GO:0035556)
calcineurin-NFAT signaling cascade [Inferred is_a relation] is_a (inferred) second-messenger-mediated signaling (GO:0019932)
calcineurin-NFAT signaling cascade [is_a relation] is_a  calcium-mediated signaling (GO:0019722)
calcineurin-NFAT signaling cascade [is_a relation] is_a  inositol phosphate-mediated signaling (GO:0048016)
Children of calcineurin-NFAT signaling cascade (GO:0033173)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
negative regulation of calcineurin-NFAT signaling cascade (GO:0070885) [negatively_regulates relation] negatively_regulates  calcineurin-NFAT signaling cascade
positive regulation of calcineurin-NFAT signaling cascade (GO:0070886) [positively_regulates relation] positively_regulates  calcineurin-NFAT signaling cascade
regulation of calcineurin-NFAT signaling cascade (GO:0070884) [regulates relation] regulates  calcineurin-NFAT signaling cascade
None.